Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies
Simultaneous stimulation of the antennal lobes (ALs) and the ascending fibers of the ventral nerve cord (AFV), two sensory inputs to the mushroom bodies (MBs), induces long-term enhancement (LTE) of subsequent AL-evoked MB responses. LTE induction requires activation of at least three signaling path...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/21076 |
| _version_ | 1828382684767846400 |
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| author | Kohei Ueno Ema Suzuki Shintaro Naganos Kyoko Ofusa Junjiro Horiuchi Minoru Saitoe |
| author_facet | Kohei Ueno Ema Suzuki Shintaro Naganos Kyoko Ofusa Junjiro Horiuchi Minoru Saitoe |
| author_sort | Kohei Ueno |
| collection | DOAJ |
| description | Simultaneous stimulation of the antennal lobes (ALs) and the ascending fibers of the ventral nerve cord (AFV), two sensory inputs to the mushroom bodies (MBs), induces long-term enhancement (LTE) of subsequent AL-evoked MB responses. LTE induction requires activation of at least three signaling pathways to the MBs, mediated by nicotinic acetylcholine receptors (nAChRs), NMDA receptors (NRs), and D1 dopamine receptors (D1Rs). Here, we demonstrate that inputs from the AL are transmitted to the MBs through nAChRs, and inputs from the AFV are transmitted by NRs. Dopamine signaling occurs downstream of both nAChR and NR activation, and requires simultaneous stimulation of both pathways. Dopamine release requires the activity of the rutabaga adenylyl cyclase in postsynaptic MB neurons, and release is restricted to MB neurons that receive coincident stimulation. Our results indicate that postsynaptic activity can gate presynaptic dopamine release to regulate plasticity. |
| first_indexed | 2024-12-10T04:36:04Z |
| format | Article |
| id | doaj.art-23e9b11eef3c435196cf2279269b92fc |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T04:36:04Z |
| publishDate | 2017-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-23e9b11eef3c435196cf2279269b92fc2022-12-22T02:02:00ZengeLife Sciences Publications LtdeLife2050-084X2017-01-01610.7554/eLife.21076Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodiesKohei Ueno0Ema Suzuki1Shintaro Naganos2Kyoko Ofusa3Junjiro Horiuchi4Minoru Saitoe5https://orcid.org/0000-0001-9731-4214Learning and Memory Project, Tokyo Metropolitan Institute of Medical Science, Setagaya, JapanLearning and Memory Project, Tokyo Metropolitan Institute of Medical Science, Setagaya, JapanLearning and Memory Project, Tokyo Metropolitan Institute of Medical Science, Setagaya, JapanLearning and Memory Project, Tokyo Metropolitan Institute of Medical Science, Setagaya, JapanLearning and Memory Project, Tokyo Metropolitan Institute of Medical Science, Setagaya, JapanLearning and Memory Project, Tokyo Metropolitan Institute of Medical Science, Setagaya, JapanSimultaneous stimulation of the antennal lobes (ALs) and the ascending fibers of the ventral nerve cord (AFV), two sensory inputs to the mushroom bodies (MBs), induces long-term enhancement (LTE) of subsequent AL-evoked MB responses. LTE induction requires activation of at least three signaling pathways to the MBs, mediated by nicotinic acetylcholine receptors (nAChRs), NMDA receptors (NRs), and D1 dopamine receptors (D1Rs). Here, we demonstrate that inputs from the AL are transmitted to the MBs through nAChRs, and inputs from the AFV are transmitted by NRs. Dopamine signaling occurs downstream of both nAChR and NR activation, and requires simultaneous stimulation of both pathways. Dopamine release requires the activity of the rutabaga adenylyl cyclase in postsynaptic MB neurons, and release is restricted to MB neurons that receive coincident stimulation. Our results indicate that postsynaptic activity can gate presynaptic dopamine release to regulate plasticity.https://elifesciences.org/articles/21076dopaminesynaptic transmissionsynaptic plasticitylearning and memory |
| spellingShingle | Kohei Ueno Ema Suzuki Shintaro Naganos Kyoko Ofusa Junjiro Horiuchi Minoru Saitoe Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies eLife dopamine synaptic transmission synaptic plasticity learning and memory |
| title | Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies |
| title_full | Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies |
| title_fullStr | Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies |
| title_full_unstemmed | Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies |
| title_short | Coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in Drosophila mushroom bodies |
| title_sort | coincident postsynaptic activity gates presynaptic dopamine release to induce plasticity in drosophila mushroom bodies |
| topic | dopamine synaptic transmission synaptic plasticity learning and memory |
| url | https://elifesciences.org/articles/21076 |
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