Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine
Blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00045/full |
| _version_ | 1819237765163778048 |
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| author | Mikaël M Martino Sime eBrkic Emmanuela eBovo Maximilian eBurger Maximilian eBurger Dirk J Schäfer Thomas eWolff Thomas eWolff Lorenz eGürke Priscilla S Briquez Hans M Larsson Roberto eGianni Barrera Jeffrey A Hubbell Jeffrey A Hubbell Jeffrey A Hubbell Andrea eBanfi |
| author_facet | Mikaël M Martino Sime eBrkic Emmanuela eBovo Maximilian eBurger Maximilian eBurger Dirk J Schäfer Thomas eWolff Thomas eWolff Lorenz eGürke Priscilla S Briquez Hans M Larsson Roberto eGianni Barrera Jeffrey A Hubbell Jeffrey A Hubbell Jeffrey A Hubbell Andrea eBanfi |
| author_sort | Mikaël M Martino |
| collection | DOAJ |
| description | Blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localization of angiogenic signals in the extracellular matrix is crucial to ensure the proper assembly and maturation of new vascular structures. Here we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of extracellular matrix to optimize the signaling microenvironment of vascular growth factors. |
| first_indexed | 2024-12-23T13:25:32Z |
| format | Article |
| id | doaj.art-23eab5087aaa4a27948b594aed3514cf |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-23T13:25:32Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-23eab5087aaa4a27948b594aed3514cf2022-12-21T17:45:19ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852015-04-01310.3389/fbioe.2015.00045134910Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicineMikaël M Martino0Sime eBrkic1Emmanuela eBovo2Maximilian eBurger3Maximilian eBurger4Dirk J Schäfer5Thomas eWolff6Thomas eWolff7Lorenz eGürke8Priscilla S Briquez9Hans M Larsson10Roberto eGianni Barrera11Jeffrey A Hubbell12Jeffrey A Hubbell13Jeffrey A Hubbell14Andrea eBanfi15Osaka UniversityBasel University HospitalBasel University HospitalBasel University HospitalBasel University HospitalBasel University HospitalBasel University HospitalBasel University HospitalBasel University HospitalEcole Polytechnique Fédérale de Lausanne (EPFL)Ecole Polytechnique Fédérale de Lausanne (EPFL)Basel University HospitalEcole Polytechnique Fédérale de Lausanne (EPFL)University of ChicagoArgonne National LaboratoryBasel University HospitalBlood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localization of angiogenic signals in the extracellular matrix is crucial to ensure the proper assembly and maturation of new vascular structures. Here we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of extracellular matrix to optimize the signaling microenvironment of vascular growth factors.http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00045/fullExtracellular MatrixFibrinProtein EngineeringAngiogenesisgrowth factors |
| spellingShingle | Mikaël M Martino Sime eBrkic Emmanuela eBovo Maximilian eBurger Maximilian eBurger Dirk J Schäfer Thomas eWolff Thomas eWolff Lorenz eGürke Priscilla S Briquez Hans M Larsson Roberto eGianni Barrera Jeffrey A Hubbell Jeffrey A Hubbell Jeffrey A Hubbell Andrea eBanfi Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine Frontiers in Bioengineering and Biotechnology Extracellular Matrix Fibrin Protein Engineering Angiogenesis growth factors |
| title | Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine |
| title_full | Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine |
| title_fullStr | Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine |
| title_full_unstemmed | Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine |
| title_short | Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine |
| title_sort | extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine |
| topic | Extracellular Matrix Fibrin Protein Engineering Angiogenesis growth factors |
| url | http://journal.frontiersin.org/Journal/10.3389/fbioe.2015.00045/full |
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