Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea
Background/Aims Hepatitis A virus (HAV) is a self-limiting infectious disease, but 1% of subjects develop fulminant hepatitis. The prevalence of the anti-HAV immunoglobulin G (IgG) antibody in hemodialysis subjects in Korea remains unknown. The purpose of this study was to describe and compare the s...
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2019-11-01
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| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://www.kjim.org/upload/pdf/kjim-2017-293.pdf |
| _version_ | 1819081048914395136 |
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| author | Hyunsuk Kim Jiwon Ryu Young-Ki Lee Myung Jin Choi Ajin Cho Ja-Ryong Koo Sae Yun Baik Eun Hee Lee Jong-Woo Yoon Jung-Woo Noh |
| author_facet | Hyunsuk Kim Jiwon Ryu Young-Ki Lee Myung Jin Choi Ajin Cho Ja-Ryong Koo Sae Yun Baik Eun Hee Lee Jong-Woo Yoon Jung-Woo Noh |
| author_sort | Hyunsuk Kim |
| collection | DOAJ |
| description | Background/Aims Hepatitis A virus (HAV) is a self-limiting infectious disease, but 1% of subjects develop fulminant hepatitis. The prevalence of the anti-HAV immunoglobulin G (IgG) antibody in hemodialysis subjects in Korea remains unknown. The purpose of this study was to describe and compare the seropositive rate of anti-HAV antibody among hemodialysis subjects in two hospitals according to age group. Methods A total of 170 hemodialysis subjects were evaluated for the seropositive rate of the anti-HAV IgG antibody and its titer. Results Of the 170 maintenance hemodialysis subjects in two hospitals (Kangnam 92 vs. Chuncheon 78), 79 (46.5%) were male. The mean age was 53.2 years old, and 94.1% of the subjects were over 40 years old. The median vintage of hemodialysis was 29.0 months. Anti-HAV antibody was found in 163 subjects (95.9%), with no significant difference between the two areas (Kangnam 97.8% [n = 90] vs. Chuncheon 93.6% [n = 73]). Subjects younger than 40 years old showed a seropositive rate of 50%, while the seropositive rate increased with age for subjects aged 40 or older (p for trend < 0.001). Seropositive subjects from Kangnam showed a higher anti-HAV antibody titer than those from Chuncheon (median: Kangnam 14.2 vs. Chuncheon 11.7). Only age influenced seropositivity. The only factor that influenced the antibody level was the location of hospital (p < 0.001). Conclusions The seropositive rate of the anti-HAV antibody in hemodialysis subjects was 95%, which is similar to findings in the general population. Active immunization against hepatitis A is strongly recommended for hemodialysis subjects under 40 years of age after anti-HAV testing. |
| first_indexed | 2024-12-21T19:54:35Z |
| format | Article |
| id | doaj.art-23ec29d142444600944f721fd6c1fcfb |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-21T19:54:35Z |
| publishDate | 2019-11-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-23ec29d142444600944f721fd6c1fcfb2022-12-21T18:52:08ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482019-11-013461297130310.3904/kjim.2017.293170021Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in KoreaHyunsuk Kim0Jiwon Ryu1Young-Ki Lee2Myung Jin Choi3Ajin Cho4Ja-Ryong Koo5Sae Yun Baik6Eun Hee Lee7Jong-Woo Yoon8Jung-Woo Noh9 Division of Nephrology, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea Division of Nephrology, Department of Internal Medicine, Cheju Halla Hospital; Jeju, Korea Division of Nephrology, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea Division of Nephrology, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea Division of Nephrology, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea Division of Nephrology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea Laboratory Medicine, Green Cross Laboratories, Youngin, Korea Laboratory Medicine, Green Cross Laboratories, Youngin, Korea Division of Nephrology, Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Korea Division of Nephrology, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, KoreaBackground/Aims Hepatitis A virus (HAV) is a self-limiting infectious disease, but 1% of subjects develop fulminant hepatitis. The prevalence of the anti-HAV immunoglobulin G (IgG) antibody in hemodialysis subjects in Korea remains unknown. The purpose of this study was to describe and compare the seropositive rate of anti-HAV antibody among hemodialysis subjects in two hospitals according to age group. Methods A total of 170 hemodialysis subjects were evaluated for the seropositive rate of the anti-HAV IgG antibody and its titer. Results Of the 170 maintenance hemodialysis subjects in two hospitals (Kangnam 92 vs. Chuncheon 78), 79 (46.5%) were male. The mean age was 53.2 years old, and 94.1% of the subjects were over 40 years old. The median vintage of hemodialysis was 29.0 months. Anti-HAV antibody was found in 163 subjects (95.9%), with no significant difference between the two areas (Kangnam 97.8% [n = 90] vs. Chuncheon 93.6% [n = 73]). Subjects younger than 40 years old showed a seropositive rate of 50%, while the seropositive rate increased with age for subjects aged 40 or older (p for trend < 0.001). Seropositive subjects from Kangnam showed a higher anti-HAV antibody titer than those from Chuncheon (median: Kangnam 14.2 vs. Chuncheon 11.7). Only age influenced seropositivity. The only factor that influenced the antibody level was the location of hospital (p < 0.001). Conclusions The seropositive rate of the anti-HAV antibody in hemodialysis subjects was 95%, which is similar to findings in the general population. Active immunization against hepatitis A is strongly recommended for hemodialysis subjects under 40 years of age after anti-HAV testing.http://www.kjim.org/upload/pdf/kjim-2017-293.pdfhepatitis a antibodiesantibody titerhemodialysisseroepidemiologic studies |
| spellingShingle | Hyunsuk Kim Jiwon Ryu Young-Ki Lee Myung Jin Choi Ajin Cho Ja-Ryong Koo Sae Yun Baik Eun Hee Lee Jong-Woo Yoon Jung-Woo Noh Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea The Korean Journal of Internal Medicine hepatitis a antibodies antibody titer hemodialysis seroepidemiologic studies |
| title | Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea |
| title_full | Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea |
| title_fullStr | Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea |
| title_full_unstemmed | Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea |
| title_short | Seropositive rate of the anti-hepatitis A immunoglobulin G antibody in maintenance hemodialysis subjects from two hospitals in Korea |
| title_sort | seropositive rate of the anti hepatitis a immunoglobulin g antibody in maintenance hemodialysis subjects from two hospitals in korea |
| topic | hepatitis a antibodies antibody titer hemodialysis seroepidemiologic studies |
| url | http://www.kjim.org/upload/pdf/kjim-2017-293.pdf |
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