Effects of gonadotropin-releasing hormone agonist (GnRH-a) as luteal phase support in intracytoplasmic sperm injection (ICSI) cycles: a randomized controlled trial
Abstract Background This paper describes a blind randomized controlled trial (RCT) designed to evaluate the effect of gonadotropin-releasing hormone agonist (GnRH-a) administration on outcomes of intracytoplasmic sperm injection (ICSI) in subjects stimulated with the gonadotropin-releasing hormone (...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-06-01
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| Series: | Middle East Fertility Society Journal |
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| Online Access: | http://link.springer.com/article/10.1186/s43043-020-00030-7 |
| _version_ | 1811222705447370752 |
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| author | Nasrin Saharkhiz Saghar Salehpour Sedighe Hosseini Hossein Hosseinirad Leila Nazari |
| author_facet | Nasrin Saharkhiz Saghar Salehpour Sedighe Hosseini Hossein Hosseinirad Leila Nazari |
| author_sort | Nasrin Saharkhiz |
| collection | DOAJ |
| description | Abstract Background This paper describes a blind randomized controlled trial (RCT) designed to evaluate the effect of gonadotropin-releasing hormone agonist (GnRH-a) administration on outcomes of intracytoplasmic sperm injection (ICSI) in subjects stimulated with the gonadotropin-releasing hormone (GnRH) antagonist protocol. A total of 268 women who underwent ICSI cycles with GnRH antagonist ovarian stimulation protocol were included in the study. Patients were randomly assigned to the intervention (GnRH-a) and control groups. The intervention group received a single dose injection of triptorelin (0.1 mg) subcutaneously 6 days after oocyte retrieval while the control group received placebo. The rates of chemical and clinical pregnancy were defined as the primary outcome values. Results Two hundred forty participants accomplished the study, and their data were analyzed. No significant difference was detected between the chemical pregnancy rates of the intervention and control groups. However, the clinical pregnancy rate was significantly higher in the GnRH-a group than in the placebo group. Conclusions The findings of the present study suggest that the GnRH-a support in the luteal phase can result in a significant improvement of pregnancy rates in ICSI cycles following the ovarian stimulation with GnRH antagonist protocol. |
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| format | Article |
| id | doaj.art-23ec4f83aef349d1a931cd3919849b45 |
| institution | Directory Open Access Journal |
| issn | 2090-3251 |
| language | English |
| last_indexed | 2024-04-12T08:20:41Z |
| publishDate | 2020-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Fertility Society Journal |
| spelling | doaj.art-23ec4f83aef349d1a931cd3919849b452022-12-22T03:40:36ZengSpringerOpenMiddle East Fertility Society Journal2090-32512020-06-012511610.1186/s43043-020-00030-7Effects of gonadotropin-releasing hormone agonist (GnRH-a) as luteal phase support in intracytoplasmic sperm injection (ICSI) cycles: a randomized controlled trialNasrin Saharkhiz0Saghar Salehpour1Sedighe Hosseini2Hossein Hosseinirad3Leila Nazari4Department of Obstetrics and Gynecology, School of Medicine, Preventative Gynecology Research Center, Shahid Beheshti University of Medical SciencesDepartment of Obstetrics and Gynecology, School of Medicine, Preventative Gynecology Research Center, Shahid Beheshti University of Medical SciencesDepartment of Obstetrics and Gynecology, School of Medicine, Preventative Gynecology Research Center, Shahid Beheshti University of Medical SciencesDepartment of Cell Biology and Anatomical Science, Faculty of Medicine, Student Research Committee, Shahid Beheshti University of Medical SciencesDepartment of Obstetrics and Gynecology, School of Medicine, Preventative Gynecology Research Center, Shahid Beheshti University of Medical SciencesAbstract Background This paper describes a blind randomized controlled trial (RCT) designed to evaluate the effect of gonadotropin-releasing hormone agonist (GnRH-a) administration on outcomes of intracytoplasmic sperm injection (ICSI) in subjects stimulated with the gonadotropin-releasing hormone (GnRH) antagonist protocol. A total of 268 women who underwent ICSI cycles with GnRH antagonist ovarian stimulation protocol were included in the study. Patients were randomly assigned to the intervention (GnRH-a) and control groups. The intervention group received a single dose injection of triptorelin (0.1 mg) subcutaneously 6 days after oocyte retrieval while the control group received placebo. The rates of chemical and clinical pregnancy were defined as the primary outcome values. Results Two hundred forty participants accomplished the study, and their data were analyzed. No significant difference was detected between the chemical pregnancy rates of the intervention and control groups. However, the clinical pregnancy rate was significantly higher in the GnRH-a group than in the placebo group. Conclusions The findings of the present study suggest that the GnRH-a support in the luteal phase can result in a significant improvement of pregnancy rates in ICSI cycles following the ovarian stimulation with GnRH antagonist protocol.http://link.springer.com/article/10.1186/s43043-020-00030-7Luteal phaseGnRH agonistIntracytoplasmic sperm injectionPregnancy rate |
| spellingShingle | Nasrin Saharkhiz Saghar Salehpour Sedighe Hosseini Hossein Hosseinirad Leila Nazari Effects of gonadotropin-releasing hormone agonist (GnRH-a) as luteal phase support in intracytoplasmic sperm injection (ICSI) cycles: a randomized controlled trial Middle East Fertility Society Journal Luteal phase GnRH agonist Intracytoplasmic sperm injection Pregnancy rate |
| title | Effects of gonadotropin-releasing hormone agonist (GnRH-a) as luteal phase support in intracytoplasmic sperm injection (ICSI) cycles: a randomized controlled trial |
| title_full | Effects of gonadotropin-releasing hormone agonist (GnRH-a) as luteal phase support in intracytoplasmic sperm injection (ICSI) cycles: a randomized controlled trial |
| title_fullStr | Effects of gonadotropin-releasing hormone agonist (GnRH-a) as luteal phase support in intracytoplasmic sperm injection (ICSI) cycles: a randomized controlled trial |
| title_full_unstemmed | Effects of gonadotropin-releasing hormone agonist (GnRH-a) as luteal phase support in intracytoplasmic sperm injection (ICSI) cycles: a randomized controlled trial |
| title_short | Effects of gonadotropin-releasing hormone agonist (GnRH-a) as luteal phase support in intracytoplasmic sperm injection (ICSI) cycles: a randomized controlled trial |
| title_sort | effects of gonadotropin releasing hormone agonist gnrh a as luteal phase support in intracytoplasmic sperm injection icsi cycles a randomized controlled trial |
| topic | Luteal phase GnRH agonist Intracytoplasmic sperm injection Pregnancy rate |
| url | http://link.springer.com/article/10.1186/s43043-020-00030-7 |
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