Collagen-Based Hydrogels for the Eye: A Comprehensive Review

Collagen-based hydrogels have emerged as a highly promising platform for diverse applications in ophthalmology, spanning from drug delivery systems to biomedical interventions. This review explores the diverse sources of collagen, which give rise to different types of collagen protein. The critical...

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Main Authors: Dhwani Rana, Nimeet Desai, Sagar Salave, Bharathi Karunakaran, Jyotsnendu Giri, Derajram Benival, Srividya Gorantla, Nagavendra Kommineni
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Gels
Subjects:
Online Access:https://www.mdpi.com/2310-2861/9/8/643
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author Dhwani Rana
Nimeet Desai
Sagar Salave
Bharathi Karunakaran
Jyotsnendu Giri
Derajram Benival
Srividya Gorantla
Nagavendra Kommineni
author_facet Dhwani Rana
Nimeet Desai
Sagar Salave
Bharathi Karunakaran
Jyotsnendu Giri
Derajram Benival
Srividya Gorantla
Nagavendra Kommineni
author_sort Dhwani Rana
collection DOAJ
description Collagen-based hydrogels have emerged as a highly promising platform for diverse applications in ophthalmology, spanning from drug delivery systems to biomedical interventions. This review explores the diverse sources of collagen, which give rise to different types of collagen protein. The critical isolation and purification steps are discussed, emphasizing their pivotal role in preparing collagen for biomedical use. To ensure collagen quality and purity, and the suitability of collagen for targeted applications, a comprehensive characterization and quality control are essential, encompassing assessments of its physical, chemical, and biological properties. Also, various cross-linking collagen methods have been examined for providing insight into this crucial process. This comprehensive review delves into every facet of collagen and explores the wide-ranging applications of collagen-based hydrogels, with a particular emphasis on their use in drug delivery systems and their potential in diverse biomedical interventions. By consolidating current knowledge and advancements in the field, this review aims to provide a detailed overview of the utilization of engineered collagen-based hydrogels in ocular therapeutics.
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spelling doaj.art-23ec986c5dc14a3684a029fc0404accb2023-11-19T01:13:43ZengMDPI AGGels2310-28612023-08-019864310.3390/gels9080643Collagen-Based Hydrogels for the Eye: A Comprehensive ReviewDhwani Rana0Nimeet Desai1Sagar Salave2Bharathi Karunakaran3Jyotsnendu Giri4Derajram Benival5Srividya Gorantla6Nagavendra Kommineni7National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, IndiaDepartment of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, Telangana, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, IndiaDepartment of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi 502285, Telangana, IndiaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad 382355, Gujarat, IndiaDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USACenter for Biomedical Research, Population Council, New York, NY 10065, USACollagen-based hydrogels have emerged as a highly promising platform for diverse applications in ophthalmology, spanning from drug delivery systems to biomedical interventions. This review explores the diverse sources of collagen, which give rise to different types of collagen protein. The critical isolation and purification steps are discussed, emphasizing their pivotal role in preparing collagen for biomedical use. To ensure collagen quality and purity, and the suitability of collagen for targeted applications, a comprehensive characterization and quality control are essential, encompassing assessments of its physical, chemical, and biological properties. Also, various cross-linking collagen methods have been examined for providing insight into this crucial process. This comprehensive review delves into every facet of collagen and explores the wide-ranging applications of collagen-based hydrogels, with a particular emphasis on their use in drug delivery systems and their potential in diverse biomedical interventions. By consolidating current knowledge and advancements in the field, this review aims to provide a detailed overview of the utilization of engineered collagen-based hydrogels in ocular therapeutics.https://www.mdpi.com/2310-2861/9/8/643collagenhydrogeleyedrug deliverybiomedical applications
spellingShingle Dhwani Rana
Nimeet Desai
Sagar Salave
Bharathi Karunakaran
Jyotsnendu Giri
Derajram Benival
Srividya Gorantla
Nagavendra Kommineni
Collagen-Based Hydrogels for the Eye: A Comprehensive Review
Gels
collagen
hydrogel
eye
drug delivery
biomedical applications
title Collagen-Based Hydrogels for the Eye: A Comprehensive Review
title_full Collagen-Based Hydrogels for the Eye: A Comprehensive Review
title_fullStr Collagen-Based Hydrogels for the Eye: A Comprehensive Review
title_full_unstemmed Collagen-Based Hydrogels for the Eye: A Comprehensive Review
title_short Collagen-Based Hydrogels for the Eye: A Comprehensive Review
title_sort collagen based hydrogels for the eye a comprehensive review
topic collagen
hydrogel
eye
drug delivery
biomedical applications
url https://www.mdpi.com/2310-2861/9/8/643
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AT bharathikarunakaran collagenbasedhydrogelsfortheeyeacomprehensivereview
AT jyotsnendugiri collagenbasedhydrogelsfortheeyeacomprehensivereview
AT derajrambenival collagenbasedhydrogelsfortheeyeacomprehensivereview
AT srividyagorantla collagenbasedhydrogelsfortheeyeacomprehensivereview
AT nagavendrakommineni collagenbasedhydrogelsfortheeyeacomprehensivereview