Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation

Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation

Cadmium (Cd), the common environmental pollutant, primarily targets at renal proximal tubules and induces nephrotoxicity. Cellular senescence, a phenomenon of cell growth arrest and a characteristics of maladaptive cell self-repair, is associated with renal disease progression. However, whether and...

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Bibliographic Details
Main Authors:	Xin Chou, Xiaohu Li, Zhen Min, Fan Ding, Kunpeng Ma, Yue Shen, Daoyuan Sun, Qing Wu
Format:	Article
Language:	English
Published:	Elsevier 2022-10-01
Series:	Ecotoxicology and Environmental Safety
Subjects:	Cd SIRT1 Proximal tubular epithelial cell Cell premature senescence
Online Access:	http://www.sciencedirect.com/science/article/pii/S0147651322009381

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