Pole-to-pole involvement of varicella zoster virus reactivation following COVID-19 vaccination
The aim of this study is to report the clinical features, imaging findings including confocal imaging, corneal nerve fiber analysis, and management outcomes in a series of three cases of varicella zoster virus (VZV) reactivation following one dose of coronavirus disease 2019 (COVID-19) vaccination....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=5;spage=2001;epage=2007;aulast=Mahendradas |
| _version_ | 1797775135740002304 |
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| author | Padmamalini Mahendradas Yash Parmar Sai Bhakti Mishra Aditya Patil Ankush Kawali Srinivasan Sanjay Bhujang Shetty |
| author_facet | Padmamalini Mahendradas Yash Parmar Sai Bhakti Mishra Aditya Patil Ankush Kawali Srinivasan Sanjay Bhujang Shetty |
| author_sort | Padmamalini Mahendradas |
| collection | DOAJ |
| description | The aim of this study is to report the clinical features, imaging findings including confocal imaging, corneal nerve fiber analysis, and management outcomes in a series of three cases of varicella zoster virus (VZV) reactivation following one dose of coronavirus disease 2019 (COVID-19) vaccination. This was a retrospective and observational study. All the patients who developed uveitis post-vaccination were pooled together. Patients who had VZV reactivation were included. Two cases had polymerase chain reaction positive for VZV from aqueous humor. At the time of presentation, IgG and IgM spike protein antibodies for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were tested. Out of this pool, three patients with classical features to describe pole-to-pole manifestations were chosen. A 36-year-old lady with post-vaccination sclerokeratouveitis associated with reactivation of herpes zoster ophthalmicus, a 56-year-old lady with post-vaccination acute anterior uveitis associated with herpes zoster ophthalmicus, and a 43-year-old gentleman with post-vaccination acute retinal necrosis were included. We present a possible link between anti-SARS-CoV-2 virus vaccination and varicella zoster reactivation in these patients and also describe the clinical features, imaging findings including confocal imaging, corneal nerve fiber analysis, and management with detailed discussion. |
| first_indexed | 2024-03-12T22:31:21Z |
| format | Article |
| id | doaj.art-23ed96e7a2f94b1c88c559232a7d439d |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-03-12T22:31:21Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-23ed96e7a2f94b1c88c559232a7d439d2023-07-21T15:14:09ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892023-01-017152001200710.4103/IJO.IJO_2942_22Pole-to-pole involvement of varicella zoster virus reactivation following COVID-19 vaccinationPadmamalini MahendradasYash ParmarSai Bhakti MishraAditya PatilAnkush KawaliSrinivasan SanjayBhujang ShettyThe aim of this study is to report the clinical features, imaging findings including confocal imaging, corneal nerve fiber analysis, and management outcomes in a series of three cases of varicella zoster virus (VZV) reactivation following one dose of coronavirus disease 2019 (COVID-19) vaccination. This was a retrospective and observational study. All the patients who developed uveitis post-vaccination were pooled together. Patients who had VZV reactivation were included. Two cases had polymerase chain reaction positive for VZV from aqueous humor. At the time of presentation, IgG and IgM spike protein antibodies for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) were tested. Out of this pool, three patients with classical features to describe pole-to-pole manifestations were chosen. A 36-year-old lady with post-vaccination sclerokeratouveitis associated with reactivation of herpes zoster ophthalmicus, a 56-year-old lady with post-vaccination acute anterior uveitis associated with herpes zoster ophthalmicus, and a 43-year-old gentleman with post-vaccination acute retinal necrosis were included. We present a possible link between anti-SARS-CoV-2 virus vaccination and varicella zoster reactivation in these patients and also describe the clinical features, imaging findings including confocal imaging, corneal nerve fiber analysis, and management with detailed discussion.http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=5;spage=2001;epage=2007;aulast=Mahendradascorneal nerve fiber analysiscovid-19herpes zostervaccinationvaricella zoster virus |
| spellingShingle | Padmamalini Mahendradas Yash Parmar Sai Bhakti Mishra Aditya Patil Ankush Kawali Srinivasan Sanjay Bhujang Shetty Pole-to-pole involvement of varicella zoster virus reactivation following COVID-19 vaccination Indian Journal of Ophthalmology corneal nerve fiber analysis covid-19 herpes zoster vaccination varicella zoster virus |
| title | Pole-to-pole involvement of varicella zoster virus reactivation following COVID-19 vaccination |
| title_full | Pole-to-pole involvement of varicella zoster virus reactivation following COVID-19 vaccination |
| title_fullStr | Pole-to-pole involvement of varicella zoster virus reactivation following COVID-19 vaccination |
| title_full_unstemmed | Pole-to-pole involvement of varicella zoster virus reactivation following COVID-19 vaccination |
| title_short | Pole-to-pole involvement of varicella zoster virus reactivation following COVID-19 vaccination |
| title_sort | pole to pole involvement of varicella zoster virus reactivation following covid 19 vaccination |
| topic | corneal nerve fiber analysis covid-19 herpes zoster vaccination varicella zoster virus |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2023;volume=71;issue=5;spage=2001;epage=2007;aulast=Mahendradas |
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