Sudden Sensorineural Hearing Loss in the COVID-19 Pandemic: A Systematic Review and Meta-Analysis
Introduction: Accumulating data indicate that patients with COVID-19 could be affected by sudden sensorineural hearing loss (SSNHL). The aim of the study was to analyze the epidemiological and clinical trend of SSNHL occurrence during the COVID-19 pandemic by applying a systematic review and meta-an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/12/3139 |
| _version_ | 1797460583809810432 |
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| author | Andrea Frosolini Leonardo Franz Antonio Daloiso Cosimo de Filippis Gino Marioni |
| author_facet | Andrea Frosolini Leonardo Franz Antonio Daloiso Cosimo de Filippis Gino Marioni |
| author_sort | Andrea Frosolini |
| collection | DOAJ |
| description | Introduction: Accumulating data indicate that patients with COVID-19 could be affected by sudden sensorineural hearing loss (SSNHL). The aim of the study was to analyze the epidemiological and clinical trend of SSNHL occurrence during the COVID-19 pandemic by applying a systematic review and meta-analysis approach. Methods: PubMed, Scopus, Web of Science, ScienceDirect, and Cochrane databases were searched. Results: The seven included studies had adequate relevance to the topic and the quality was fair. The mean age at SSNHL onset ranged from 39.23 to 62.18 years during the pandemic year period (PYP); a meta-analysis of four studies comparing these data with those of previous periods in the same institutions found a younger age during the PYP (pooled mean −0.2848). The heterogeneity was high (76.1935%) and no frank asymmetry was observed in the funnel plot. The SARS-CoV-2 positivity rate of SSNHL patients ranged from 0% to 57.53%. Standard steroid treatments were applied without significant adverse effects. Comprehensively, hearing improvement was achieved for more than half of the cases. No studies reported long-term follow-up data. Conclusions: Further prospective analyses on large series and a long-term follow up on COVID-related SSNHL cases are necessary to address the open questions regarding the causative link between COVID-19 infection and SSNHL. |
| first_indexed | 2024-03-09T17:08:07Z |
| format | Article |
| id | doaj.art-23edfa303efe4f919ce0cfc5c78ad30b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T17:08:07Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-23edfa303efe4f919ce0cfc5c78ad30b2023-11-24T14:19:22ZengMDPI AGDiagnostics2075-44182022-12-011212313910.3390/diagnostics12123139Sudden Sensorineural Hearing Loss in the COVID-19 Pandemic: A Systematic Review and Meta-AnalysisAndrea Frosolini0Leonardo Franz1Antonio Daloiso2Cosimo de Filippis3Gino Marioni4Audiology Unit, Department of Neuroscience DNS, University of Padova, 31100 Treviso, ItalyAudiology Unit, Department of Neuroscience DNS, University of Padova, 31100 Treviso, ItalyOtolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, ItalyAudiology Unit, Department of Neuroscience DNS, University of Padova, 31100 Treviso, ItalyOtolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, ItalyIntroduction: Accumulating data indicate that patients with COVID-19 could be affected by sudden sensorineural hearing loss (SSNHL). The aim of the study was to analyze the epidemiological and clinical trend of SSNHL occurrence during the COVID-19 pandemic by applying a systematic review and meta-analysis approach. Methods: PubMed, Scopus, Web of Science, ScienceDirect, and Cochrane databases were searched. Results: The seven included studies had adequate relevance to the topic and the quality was fair. The mean age at SSNHL onset ranged from 39.23 to 62.18 years during the pandemic year period (PYP); a meta-analysis of four studies comparing these data with those of previous periods in the same institutions found a younger age during the PYP (pooled mean −0.2848). The heterogeneity was high (76.1935%) and no frank asymmetry was observed in the funnel plot. The SARS-CoV-2 positivity rate of SSNHL patients ranged from 0% to 57.53%. Standard steroid treatments were applied without significant adverse effects. Comprehensively, hearing improvement was achieved for more than half of the cases. No studies reported long-term follow-up data. Conclusions: Further prospective analyses on large series and a long-term follow up on COVID-related SSNHL cases are necessary to address the open questions regarding the causative link between COVID-19 infection and SSNHL.https://www.mdpi.com/2075-4418/12/12/3139sudden sensorineural hearing lossSSNHLSARS-CoV-2COVID-19 |
| spellingShingle | Andrea Frosolini Leonardo Franz Antonio Daloiso Cosimo de Filippis Gino Marioni Sudden Sensorineural Hearing Loss in the COVID-19 Pandemic: A Systematic Review and Meta-Analysis Diagnostics sudden sensorineural hearing loss SSNHL SARS-CoV-2 COVID-19 |
| title | Sudden Sensorineural Hearing Loss in the COVID-19 Pandemic: A Systematic Review and Meta-Analysis |
| title_full | Sudden Sensorineural Hearing Loss in the COVID-19 Pandemic: A Systematic Review and Meta-Analysis |
| title_fullStr | Sudden Sensorineural Hearing Loss in the COVID-19 Pandemic: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Sudden Sensorineural Hearing Loss in the COVID-19 Pandemic: A Systematic Review and Meta-Analysis |
| title_short | Sudden Sensorineural Hearing Loss in the COVID-19 Pandemic: A Systematic Review and Meta-Analysis |
| title_sort | sudden sensorineural hearing loss in the covid 19 pandemic a systematic review and meta analysis |
| topic | sudden sensorineural hearing loss SSNHL SARS-CoV-2 COVID-19 |
| url | https://www.mdpi.com/2075-4418/12/12/3139 |
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