Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel diseaseResearch in context

Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel diseaseResearch in context

Summary: Background: Mitochondrial dysfunction has been linked to the development of inflammatory bowel disease (IBD), but the genetic pathophysiology was not fully elucidated. We employed Mendelian randomization and colocalization analyses to investigate the associations between mitochondrial-rela...

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Bibliographic Details
Main Authors: Jie Chen, Xixian Ruan, Yuhao Sun, Shiyuan Lu, Shixian Hu, Shuai Yuan, Xue Li
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:EBioMedicine
Subjects:
Inflammatory bowel disease
Mendelian randomization
Mitochondrion
Methylation
Gene expression
Protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423005005

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