Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria
Parasitic nematode infections cause debilitating diseases and impede economic productivity. Antinematode chemotherapies are fundamental to modern medicine and are also important for industries including agriculture, aquaculture and animal health. However, the lack of suitable treatments for some dis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/8/12/1963 |
| _version_ | 1797545000353923072 |
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| author | Nor Hawani Salikin Jadranka Nappi Marwan E. Majzoub Suhelen Egan |
| author_facet | Nor Hawani Salikin Jadranka Nappi Marwan E. Majzoub Suhelen Egan |
| author_sort | Nor Hawani Salikin |
| collection | DOAJ |
| description | Parasitic nematode infections cause debilitating diseases and impede economic productivity. Antinematode chemotherapies are fundamental to modern medicine and are also important for industries including agriculture, aquaculture and animal health. However, the lack of suitable treatments for some diseases and the rise of nematode resistance to many available therapies necessitates the discovery and development of new drugs. Here, marine epiphytic bacteria represent a promising repository of newly discovered antinematode compounds. Epiphytic bacteria are ubiquitous on marine surfaces where they are under constant pressure of grazing by bacterivorous predators (e.g., protozoans and nematodes). Studies have shown that these bacteria have developed defense strategies to prevent grazers by producing toxic bioactive compounds. Although several active metabolites against nematodes have been identified from marine bacteria, drug discovery from marine microorganisms remains underexplored. In this review, we aim to provide further insight into the need and potential for marine epiphytic bacteria to become a new source of antinematode drugs. We discuss current and emerging strategies, including culture-independent high throughput screening and the utilization of <i>Caenorhabditis elegans</i> as a model target organism, which will be required to advance antinematode drug discovery and development from marine microbial sources. |
| first_indexed | 2024-03-10T14:09:28Z |
| format | Article |
| id | doaj.art-23f37a4364644ae9a28356b2649a429e |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T14:09:28Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-23f37a4364644ae9a28356b2649a429e2023-11-21T00:18:03ZengMDPI AGMicroorganisms2076-26072020-12-01812196310.3390/microorganisms8121963Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic BacteriaNor Hawani Salikin0Jadranka Nappi1Marwan E. Majzoub2Suhelen Egan3Centre for Marine Science and Innovation, School of Biological, Earth and Environmental Sciences, UNSW, Sydney, NSW 2052, AustraliaCentre for Marine Science and Innovation, School of Biological, Earth and Environmental Sciences, UNSW, Sydney, NSW 2052, AustraliaCentre for Marine Science and Innovation, School of Biological, Earth and Environmental Sciences, UNSW, Sydney, NSW 2052, AustraliaCentre for Marine Science and Innovation, School of Biological, Earth and Environmental Sciences, UNSW, Sydney, NSW 2052, AustraliaParasitic nematode infections cause debilitating diseases and impede economic productivity. Antinematode chemotherapies are fundamental to modern medicine and are also important for industries including agriculture, aquaculture and animal health. However, the lack of suitable treatments for some diseases and the rise of nematode resistance to many available therapies necessitates the discovery and development of new drugs. Here, marine epiphytic bacteria represent a promising repository of newly discovered antinematode compounds. Epiphytic bacteria are ubiquitous on marine surfaces where they are under constant pressure of grazing by bacterivorous predators (e.g., protozoans and nematodes). Studies have shown that these bacteria have developed defense strategies to prevent grazers by producing toxic bioactive compounds. Although several active metabolites against nematodes have been identified from marine bacteria, drug discovery from marine microorganisms remains underexplored. In this review, we aim to provide further insight into the need and potential for marine epiphytic bacteria to become a new source of antinematode drugs. We discuss current and emerging strategies, including culture-independent high throughput screening and the utilization of <i>Caenorhabditis elegans</i> as a model target organism, which will be required to advance antinematode drug discovery and development from marine microbial sources.https://www.mdpi.com/2076-2607/8/12/1963antinematode compoundanthelminthic drugsmarine epiphytic bacteriamarine biofilmmarine environmentparasitic nematode |
| spellingShingle | Nor Hawani Salikin Jadranka Nappi Marwan E. Majzoub Suhelen Egan Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria Microorganisms antinematode compound anthelminthic drugs marine epiphytic bacteria marine biofilm marine environment parasitic nematode |
| title | Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria |
| title_full | Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria |
| title_fullStr | Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria |
| title_full_unstemmed | Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria |
| title_short | Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria |
| title_sort | combating parasitic nematode infections newly discovered antinematode compounds from marine epiphytic bacteria |
| topic | antinematode compound anthelminthic drugs marine epiphytic bacteria marine biofilm marine environment parasitic nematode |
| url | https://www.mdpi.com/2076-2607/8/12/1963 |
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