Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus

Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus

Background: Aspergillus fumigatus is the most prevalent airborne fungal pathogen, causing invasive fungal infections mainly in immunosuppressed individuals. Death rates from invasive aspergillosis remain high because of limited treatment options and increasing antifungal resistance. The aim of this...

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Bibliographic Details
Main Authors: Anna-Maria Dietl, Zohar Meir, Yona Shadkchan, Nir Osherov, Hubertus Haas
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Virulence
Subjects:
Aspergillus fumigatus virulence
vitamin B biosynthesis
auxotrophy
iron metabolism
antifungal drug target
Online Access:http://dx.doi.org/10.1080/21505594.2018.1482181

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