The effect of microneedles on the skin permeability and antitumor activity of topical 5-fluorouracil

The effect of microneedles on the skin permeability and antitumor activity of topical 5-fluorouracil

Topical 5-fluorouracil (5-FU) is approved for the treatment of superficial basal cell carcinoma and actinic keratosis. However, 5-FU suffers from poor skin permeation. Microneedles have been successfully applied to improve the skin permeability of small and large molecules, and even nanoparticles, b...

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Bibliographic Details
Main Authors: Youssef W. Naguib, Amit Kumar, Zhengrong Cui
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Microneedles
5-Fluorouracil
Cytotoxicity
Melanoma
Immunohistochemistry
Flux
Transdermal
Antitumor activity
Skin permeability
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383514000021

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