High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria
Abstract In a previous study, we found that higher waist circumference (WC) and higher body mass index (BMI) both increase the risk of chronic spontaneous urticaria (CSU). The aim of this study was to determine whether WC and BMI also increase the duration of CSU. We used multivariable Cox proportio...
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| Format: | Article |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-81484-1 |
| _version_ | 1818722642453069824 |
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| author | Yeong Ho Kim Kyung Do Han Chul Hwan Bang Ji Hyun Lee Jun Young Lee Yong Gyu Park Young Min Park |
| author_facet | Yeong Ho Kim Kyung Do Han Chul Hwan Bang Ji Hyun Lee Jun Young Lee Yong Gyu Park Young Min Park |
| author_sort | Yeong Ho Kim |
| collection | DOAJ |
| description | Abstract In a previous study, we found that higher waist circumference (WC) and higher body mass index (BMI) both increase the risk of chronic spontaneous urticaria (CSU). The aim of this study was to determine whether WC and BMI also increase the duration of CSU. We used multivariable Cox proportional hazards models to determine the hazard ratio (HR) for longer disease duration (longer than 3 years) according to WC and BMI. A total of 52,667 subjects were enrolled and their mean age was 54.5. After adjustments for other confounding variables the high WC/high BMI group had 1.062 times higher HR (95% CI, 1.028–1.098) than the normal WC/normal BMI group. Interestingly, the high WC/normal BMI group showed a significantly higher HR (1.053; 95% CI, 1.008–1.101) than the normal WC/normal BMI group, but not the normal WC/high BMI group (0.998; 95% CI, 0.951–1.046). Taken together, our results suggest that high WC rather than high BMI is a predictive risk factor for the longer disease duration of CSU. |
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| id | doaj.art-23f5652a9b814dec9b542164f39e72d9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T20:57:52Z |
| publishDate | 2021-01-01 |
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| spelling | doaj.art-23f5652a9b814dec9b542164f39e72d92022-12-21T21:32:49ZengNature PortfolioScientific Reports2045-23222021-01-011111410.1038/s41598-021-81484-1High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticariaYeong Ho Kim0Kyung Do Han1Chul Hwan Bang2Ji Hyun Lee3Jun Young Lee4Yong Gyu Park5Young Min Park6Department of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Statistics and Actuarial Science, Soongsil UniversityDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Biostatistics, College of Medicine, The Catholic University of KoreaDepartment of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaAbstract In a previous study, we found that higher waist circumference (WC) and higher body mass index (BMI) both increase the risk of chronic spontaneous urticaria (CSU). The aim of this study was to determine whether WC and BMI also increase the duration of CSU. We used multivariable Cox proportional hazards models to determine the hazard ratio (HR) for longer disease duration (longer than 3 years) according to WC and BMI. A total of 52,667 subjects were enrolled and their mean age was 54.5. After adjustments for other confounding variables the high WC/high BMI group had 1.062 times higher HR (95% CI, 1.028–1.098) than the normal WC/normal BMI group. Interestingly, the high WC/normal BMI group showed a significantly higher HR (1.053; 95% CI, 1.008–1.101) than the normal WC/normal BMI group, but not the normal WC/high BMI group (0.998; 95% CI, 0.951–1.046). Taken together, our results suggest that high WC rather than high BMI is a predictive risk factor for the longer disease duration of CSU.https://doi.org/10.1038/s41598-021-81484-1 |
| spellingShingle | Yeong Ho Kim Kyung Do Han Chul Hwan Bang Ji Hyun Lee Jun Young Lee Yong Gyu Park Young Min Park High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria Scientific Reports |
| title | High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria |
| title_full | High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria |
| title_fullStr | High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria |
| title_full_unstemmed | High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria |
| title_short | High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria |
| title_sort | high waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria |
| url | https://doi.org/10.1038/s41598-021-81484-1 |
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