Rapid Identification of Secondary Structure and Binding Site Residues in an Intrinsically Disordered Protein Segment

Rapid Identification of Secondary Structure and Binding Site Residues in an Intrinsically Disordered Protein Segment

Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease. The MazE antitoxin has a disordered C-terminal domain that binds the toxin, Ma...

Full description

Bibliographic Details
Main Authors:	Soumyanetra Chandra, Gopinath Chattopadhyay, Raghavan Varadarajan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-11-01
Series:	Frontiers in Genetics
Subjects:	charged mutational scanning aspartate functional residues interface protein-protein interactions protein structure
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2021.755292/full

Similar Items

Combining cysteine scanning with chemical labeling to map protein-protein interactions and infer bound structure in an intrinsically disordered region
by: Shahbaz Ahmed, et al.
Published: (2022-10-01)

Interface residues of transient protein-protein complexes have extensive intra-protein interactions apart from inter-protein interactions
by: Srinivasan Jayashree, et al.
Published: (2019-01-01)

Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library
by: Thuy-Lan V Lite, et al.
Published: (2020-10-01)

Analyses on clustering of the conserved residues at protein-RNA interfaces and its application in binding site identification
by: Zhen Yang, et al.
Published: (2020-02-01)

Editorial: From the hydrophobic core to the globular-disorder interface: New challenges and insights into protein design
by: Sankar Basu, et al.
Published: (2023-02-01)

Distinguishing crystallographic from biological interfaces in protein complexes: role of intermolecular contacts and energetics for classification
by: Katarina Elez, et al.
Published: (2018-11-01)

Basic Residue Clusters in Intrinsically Disordered Regions of Peripheral Membrane Proteins: Modulating 2D Diffusion on Cell Membranes
by: Miquel Pons
Published: (2021-07-01)

Protein-protein interface hot spots prediction based on a hybrid feature selection strategy
by: Yanhua Qiao, et al.
Published: (2018-01-01)

Docking-based identification of small-molecule binding sites at protein-protein interfaces
by: Mireia Rosell, et al.
Published: (2020-01-01)

PROT-ON: A structure-based detection of designer PROTein interface MutatiONs
by: Mehdi Koşaca, et al.
Published: (2023-03-01)

Binding Direction-Based Two-Dimensional Flattened Contact Area Computing Algorithm for Protein–Protein Interactions
by: Beom Sik Kang, et al.
Published: (2017-10-01)

Site-directed mutagenesis of cysteine to serine residues affects heparin binding and mitogenicity in fibroblast growth factor 4 produced in Escherichia coli
by: Yuki Kumagai, et al.
Published: (2019-01-01)

Protein–Protein Interactions Efficiently Modeled by Residue Cluster Classes
by: Albros Hermes Poot Velez, et al.
Published: (2020-07-01)

Targeting S100B with Peptides Encoding Intrinsic Aggregation-Prone Sequence Segments
by: Joana S. Cristóvão, et al.
Published: (2021-01-01)

Multiscale docking using evolutionary optimisation
by: Huggins, D, et al.
Published: (2005)

Systematized analysis of secondary structure dependence of key structural features of residues in soluble and membrane-bound proteins
by: Mohammed H. AL Mughram, et al.
Published: (2021-01-01)

Unfolded proteins : from denatured to intrinsically disordered /
by: Creamer, Trevor P.
Published: (c200)

Residue–Residue Interaction Prediction via Stacked Meta-Learning
by: Kuan-Hsi Chen, et al.
Published: (2021-06-01)

A Computer-Based Methodology to Design Non-Standard Peptides Potentially Able to Prevent HOX-PBX1-Associated Cancer Diseases
by: Maria Rita Gulotta, et al.
Published: (2021-05-01)

Protein–Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations
by: Eric T. C. Wong, et al.
Published: (2020-07-01)

COMTOP: Protein Residue–Residue Contact Prediction through Mixed Integer Linear Optimization
by: Md. Selim Reza, et al.
Published: (2021-06-01)

Experimentally Determined Long Intrinsically Disordered Protein Regions Are Now Abundant in the Protein Data Bank
by: Alexander Miguel Monzon, et al.
Published: (2020-06-01)

The Odd Faces of Oligomers: The Case of TRAF2-C, A Trimeric C-Terminal Domain of TNF Receptor-Associated Factor
by: Almerinda Di Venere, et al.
Published: (2021-05-01)

Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner
by: Ben M. Smith, et al.
Published: (2021-06-01)

Confirmation of the formation of salt bridges in the denatured state of CutA1 protein using molecular dynamics simulations
by: Katsuhide Yutani, et al.
Published: (2019-11-01)

A Comprehensive Study of De Novo Mutations on the Protein-Protein Interaction Interfaces Provides New Insights into Developmental Delay
by: Dhruba Tara Maharjan, et al.
Published: (2022-11-01)

Prediction of protein secondary structure based on deep residual convolutional neural network
by: Jinyong Cheng, et al.
Published: (2021-01-01)

Attention mechanism enhanced LSTM with residual architecture and its application for protein-protein interaction residue pairs prediction
by: Jiale Liu, et al.
Published: (2019-11-01)

In-Silico Analysis of pH-Dependent Liquid-Liquid Phase Separation in Intrinsically Disordered Proteins
by: Carlos Pintado-Grima, et al.
Published: (2022-07-01)

Unraveling the Thermodynamics of Ultra-tight Binding of Intrinsically Disordered Proteins
by: Uroš Zavrtanik, et al.
Published: (2021-08-01)

Binding mechanisms of intrinsically disordered proteins: theory, simulation, and experiment
by: Luca Mollica, et al.
Published: (2016-09-01)

Effective inter-residue contact definitions for accurate protein fold recognition
by: Yuan Chao, et al.
Published: (2012-11-01)

A New Tool to Study the Binding Behavior of Intrinsically Disordered Proteins
by: Aakriti Upadhyay, et al.
Published: (2023-07-01)

Establishing the mutational effect on the binding susceptibility of AMG510 to KRAS switch II binding pocket: Computational insights
by: Abdul Rashid Issahaku, et al.
Published: (2022-01-01)

RDb2C2: an improved method to identify the residue-residue pairing in β strands
by: Di Shao, et al.
Published: (2020-04-01)

The Use of Excess Electric Charge for Highly Sensitive Protein Detection: Proof of Concept
by: Sergey L. Kanashenko, et al.
Published: (2022-06-01)

Comparative Assessment of Intrinsic Disorder Predictions with a Focus on Protein and Nucleic Acid-Binding Proteins
by: Akila Katuwawala, et al.
Published: (2020-12-01)

Relationships Between Plasminogen-Binding M-Protein and Surface Enolase for Human Plasminogen Acquisition and Activation in Streptococcus pyogenes
by: Yetunde A. Ayinuola, et al.
Published: (2022-05-01)

FunFam protein families improve residue level molecular function prediction
by: Linus Scheibenreif, et al.
Published: (2019-07-01)

An engineered biosensor enables dynamic aspartate measurements in living cells
by: Kristian Davidsen, et al.
Published: (2024-02-01)