Co-Regulated Genes and Gene Clusters
There are many co-regulated genes in eukaryotic cells. The coordinated activation or repression of such genes occurs at specific stages of differentiation, or under the influence of external stimuli. As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, wh...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/6/907 |
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| author | Sergey V. Razin Elena S. Ioudinkova Omar L. Kantidze Olga V. Iarovaia |
| author_facet | Sergey V. Razin Elena S. Ioudinkova Omar L. Kantidze Olga V. Iarovaia |
| author_sort | Sergey V. Razin |
| collection | DOAJ |
| description | There are many co-regulated genes in eukaryotic cells. The coordinated activation or repression of such genes occurs at specific stages of differentiation, or under the influence of external stimuli. As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, which contain paralogous genes that encode proteins with similar functions. In this aspect, they differ significantly from bacterial operons containing functionally linked genes that are not paralogs. In this review, we discuss the reasons for the existence of gene clusters in vertebrate cells and propose that clustering is necessary to ensure the possibility of selective activation of one of several similar genes. |
| first_indexed | 2024-03-10T10:29:03Z |
| format | Article |
| id | doaj.art-23f80f0ba41145698880c0de9347dac3 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T10:29:03Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-23f80f0ba41145698880c0de9347dac32023-11-21T23:44:53ZengMDPI AGGenes2073-44252021-06-0112690710.3390/genes12060907Co-Regulated Genes and Gene ClustersSergey V. Razin0Elena S. Ioudinkova1Omar L. Kantidze2Olga V. Iarovaia3Institute of Gene Biology Russian Academy of Sciences, 119334 Moscow, RussiaInstitute of Gene Biology Russian Academy of Sciences, 119334 Moscow, RussiaInstitute of Gene Biology Russian Academy of Sciences, 119334 Moscow, RussiaInstitute of Gene Biology Russian Academy of Sciences, 119334 Moscow, RussiaThere are many co-regulated genes in eukaryotic cells. The coordinated activation or repression of such genes occurs at specific stages of differentiation, or under the influence of external stimuli. As a rule, co-regulated genes are dispersed in the genome. However, there are also gene clusters, which contain paralogous genes that encode proteins with similar functions. In this aspect, they differ significantly from bacterial operons containing functionally linked genes that are not paralogs. In this review, we discuss the reasons for the existence of gene clusters in vertebrate cells and propose that clustering is necessary to ensure the possibility of selective activation of one of several similar genes.https://www.mdpi.com/2073-4425/12/6/907co-regulated genesgene clusterscoordinated expression |
| spellingShingle | Sergey V. Razin Elena S. Ioudinkova Omar L. Kantidze Olga V. Iarovaia Co-Regulated Genes and Gene Clusters Genes co-regulated genes gene clusters coordinated expression |
| title | Co-Regulated Genes and Gene Clusters |
| title_full | Co-Regulated Genes and Gene Clusters |
| title_fullStr | Co-Regulated Genes and Gene Clusters |
| title_full_unstemmed | Co-Regulated Genes and Gene Clusters |
| title_short | Co-Regulated Genes and Gene Clusters |
| title_sort | co regulated genes and gene clusters |
| topic | co-regulated genes gene clusters coordinated expression |
| url | https://www.mdpi.com/2073-4425/12/6/907 |
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