Anti-Inflammatory Effects of GLP-1R Activation in the Retina
Glucagon-like peptide-1 (GLP-1) is an incretin hormone, mainly produced by enteroendocrine L cells, which participates in the regulation of glucose homeostasis, and in reduction in body weight by promoting satiety. Actions of GLP-1 are mediated by activation of its receptor GLP-1R, which is widely e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/20/12428 |
| _version_ | 1797472743409582080 |
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| author | Alessandra Puddu Davide Maggi |
| author_facet | Alessandra Puddu Davide Maggi |
| author_sort | Alessandra Puddu |
| collection | DOAJ |
| description | Glucagon-like peptide-1 (GLP-1) is an incretin hormone, mainly produced by enteroendocrine L cells, which participates in the regulation of glucose homeostasis, and in reduction in body weight by promoting satiety. Actions of GLP-1 are mediated by activation of its receptor GLP-1R, which is widely expressed in several tissues including the retina. The effects of GLP-1R activation are useful in the management of type 2 diabetes mellitus (T2DM). In addition, the activation of GLP-1R has anti-inflammatory effects in several organs, suggesting that it may be also useful in the treatment of inflammatory diseases. Inflammation is a common element in the pathogenesis of several ocular diseases, and the protective effects of treatment with GLP-1 emerged also in retinal diseases. In this review we highlight the anti-inflammatory effects of GLP-1R activation in the retina. Firstly, we summarized the pathogenic role of inflammation in ocular diseases. Then, we described the pleiotropic effects of GLP-1R activation on the cellular components of the retina which are mainly involved in the pathogenesis of inflammatory retinal diseases: the retinal ganglion cells, retinal pigment epithelial cells and endothelial cells. |
| first_indexed | 2024-03-09T20:05:33Z |
| format | Article |
| id | doaj.art-23fca2ec70c04bb5b2f7fc4376c90374 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:05:33Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-23fca2ec70c04bb5b2f7fc4376c903742023-11-24T00:31:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-10-0123201242810.3390/ijms232012428Anti-Inflammatory Effects of GLP-1R Activation in the RetinaAlessandra Puddu0Davide Maggi1Department of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, ItalyDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, ItalyGlucagon-like peptide-1 (GLP-1) is an incretin hormone, mainly produced by enteroendocrine L cells, which participates in the regulation of glucose homeostasis, and in reduction in body weight by promoting satiety. Actions of GLP-1 are mediated by activation of its receptor GLP-1R, which is widely expressed in several tissues including the retina. The effects of GLP-1R activation are useful in the management of type 2 diabetes mellitus (T2DM). In addition, the activation of GLP-1R has anti-inflammatory effects in several organs, suggesting that it may be also useful in the treatment of inflammatory diseases. Inflammation is a common element in the pathogenesis of several ocular diseases, and the protective effects of treatment with GLP-1 emerged also in retinal diseases. In this review we highlight the anti-inflammatory effects of GLP-1R activation in the retina. Firstly, we summarized the pathogenic role of inflammation in ocular diseases. Then, we described the pleiotropic effects of GLP-1R activation on the cellular components of the retina which are mainly involved in the pathogenesis of inflammatory retinal diseases: the retinal ganglion cells, retinal pigment epithelial cells and endothelial cells.https://www.mdpi.com/1422-0067/23/20/12428GLP-1GLP-1RGLP-1RAsdiabetic retinopathyglaucomaage-related macular degeneration |
| spellingShingle | Alessandra Puddu Davide Maggi Anti-Inflammatory Effects of GLP-1R Activation in the Retina International Journal of Molecular Sciences GLP-1 GLP-1R GLP-1RAs diabetic retinopathy glaucoma age-related macular degeneration |
| title | Anti-Inflammatory Effects of GLP-1R Activation in the Retina |
| title_full | Anti-Inflammatory Effects of GLP-1R Activation in the Retina |
| title_fullStr | Anti-Inflammatory Effects of GLP-1R Activation in the Retina |
| title_full_unstemmed | Anti-Inflammatory Effects of GLP-1R Activation in the Retina |
| title_short | Anti-Inflammatory Effects of GLP-1R Activation in the Retina |
| title_sort | anti inflammatory effects of glp 1r activation in the retina |
| topic | GLP-1 GLP-1R GLP-1RAs diabetic retinopathy glaucoma age-related macular degeneration |
| url | https://www.mdpi.com/1422-0067/23/20/12428 |
| work_keys_str_mv | AT alessandrapuddu antiinflammatoryeffectsofglp1ractivationintheretina AT davidemaggi antiinflammatoryeffectsofglp1ractivationintheretina |