Evaluation of the effects of bitter yam tuber supplementation on serum parameters used to assess hepatotoxicity and nephrotoxicity in transgenic mice
The Jamaican bitter yam (Dioscorea polygonoides) (ITIS) is known to possess potent antidiabetic and hypocholesterolemic properties and can therefore be exploited for associated nutraceutical/pharmaceutical purposes. It however possesses bioactive compounds known to promote organ damage when ingested...
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| Format: | Article |
| Language: | English |
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Plovdiv University Press
2014-08-01
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| Series: | Journal of BioScience and Biotechnology |
| Subjects: | |
| Online Access: | http://www.jbb.uni-plovdiv.bg/documents/27807/352486/jbb_2014-3(2)-pages_133-139.pdf |
| _version_ | 1811287281560977408 |
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| author | DEWAYNE K. STENNETT FREDERICK OLADEINDE ANDREW O. WHEATLEY LOWELL L. DILWORTH CHRISTINE HOHMANN JOSEPH BRYANT HELEN N. ASEMOTA |
| author_facet | DEWAYNE K. STENNETT FREDERICK OLADEINDE ANDREW O. WHEATLEY LOWELL L. DILWORTH CHRISTINE HOHMANN JOSEPH BRYANT HELEN N. ASEMOTA |
| author_sort | DEWAYNE K. STENNETT |
| collection | DOAJ |
| description | The Jamaican bitter yam (Dioscorea polygonoides) (ITIS) is known to possess potent antidiabetic and hypocholesterolemic properties and can therefore be exploited for associated nutraceutical/pharmaceutical purposes. It however possesses bioactive compounds known to promote organ damage when ingested in excess. This study investigates the effects of bitter yam consumption at a concentration of 5% on liver and kidney damage/function parameters. Normocholesterolemic mice fed bitter yam supplemented diets experienced significant increases in serum aspartate aminotransferase activity and bilirubin, magnesium and phosphorus concentrations. Significant increases were also observed in serum aspartate aminotransferase activity and blood urea nitrogen concentration of the genetically modified hypercholesterolemic mice fed supplemented diets. These results suggest mild kidney damage in both mice species and a significant increase in the rate of erythrocyte haemolysis in the normocholesterolemic mice. |
| first_indexed | 2024-04-13T03:16:08Z |
| format | Article |
| id | doaj.art-23fd2023e362437cb8e6df0e9ed1f654 |
| institution | Directory Open Access Journal |
| issn | 1314-6238 1314-6246 |
| language | English |
| last_indexed | 2024-04-13T03:16:08Z |
| publishDate | 2014-08-01 |
| publisher | Plovdiv University Press |
| record_format | Article |
| series | Journal of BioScience and Biotechnology |
| spelling | doaj.art-23fd2023e362437cb8e6df0e9ed1f6542022-12-22T03:04:55ZengPlovdiv University PressJournal of BioScience and Biotechnology1314-62381314-62462014-08-0132133139Evaluation of the effects of bitter yam tuber supplementation on serum parameters used to assess hepatotoxicity and nephrotoxicity in transgenic miceDEWAYNE K. STENNETT0FREDERICK OLADEINDE1ANDREW O. WHEATLEY2LOWELL L. DILWORTH3CHRISTINE HOHMANN4JOSEPH BRYANT5HELEN N. ASEMOTA6Department of Basic Medical Sciences, Biochemistry Section, University of the West Indies, Mona Campus Kingston 7, Jamaica. W.I Chemistry DepartmentDepartment of Basic Medical Sciences, Biochemistry Section, University of the West Indies, Mona Campus Kingston 7, Jamaica. W.I Pathology Department; Faculty of Medical Sciences, The University of the West Indies, Mona Campus, Kingston 7, JamaicaBiology Department; Morgan State University, Baltimore, Maryland, U.S.AAnimal Core Facility, Institute of Human Virology, College of Medicine, University of Maryland, Baltimore, Maryland, U.S.ADepartment of Basic Medical Sciences, Biochemistry Section, University of the West Indies, Mona Campus Kingston 7, Jamaica. W.IThe Jamaican bitter yam (Dioscorea polygonoides) (ITIS) is known to possess potent antidiabetic and hypocholesterolemic properties and can therefore be exploited for associated nutraceutical/pharmaceutical purposes. It however possesses bioactive compounds known to promote organ damage when ingested in excess. This study investigates the effects of bitter yam consumption at a concentration of 5% on liver and kidney damage/function parameters. Normocholesterolemic mice fed bitter yam supplemented diets experienced significant increases in serum aspartate aminotransferase activity and bilirubin, magnesium and phosphorus concentrations. Significant increases were also observed in serum aspartate aminotransferase activity and blood urea nitrogen concentration of the genetically modified hypercholesterolemic mice fed supplemented diets. These results suggest mild kidney damage in both mice species and a significant increase in the rate of erythrocyte haemolysis in the normocholesterolemic mice.http://www.jbb.uni-plovdiv.bg/documents/27807/352486/jbb_2014-3(2)-pages_133-139.pdftoxicityorgan damagebitter yamtransgenic miceexperimental hypercholesterolemia |
| spellingShingle | DEWAYNE K. STENNETT FREDERICK OLADEINDE ANDREW O. WHEATLEY LOWELL L. DILWORTH CHRISTINE HOHMANN JOSEPH BRYANT HELEN N. ASEMOTA Evaluation of the effects of bitter yam tuber supplementation on serum parameters used to assess hepatotoxicity and nephrotoxicity in transgenic mice Journal of BioScience and Biotechnology toxicity organ damage bitter yam transgenic mice experimental hypercholesterolemia |
| title | Evaluation of the effects of bitter yam tuber supplementation on serum parameters used to assess hepatotoxicity and nephrotoxicity in transgenic mice |
| title_full | Evaluation of the effects of bitter yam tuber supplementation on serum parameters used to assess hepatotoxicity and nephrotoxicity in transgenic mice |
| title_fullStr | Evaluation of the effects of bitter yam tuber supplementation on serum parameters used to assess hepatotoxicity and nephrotoxicity in transgenic mice |
| title_full_unstemmed | Evaluation of the effects of bitter yam tuber supplementation on serum parameters used to assess hepatotoxicity and nephrotoxicity in transgenic mice |
| title_short | Evaluation of the effects of bitter yam tuber supplementation on serum parameters used to assess hepatotoxicity and nephrotoxicity in transgenic mice |
| title_sort | evaluation of the effects of bitter yam tuber supplementation on serum parameters used to assess hepatotoxicity and nephrotoxicity in transgenic mice |
| topic | toxicity organ damage bitter yam transgenic mice experimental hypercholesterolemia |
| url | http://www.jbb.uni-plovdiv.bg/documents/27807/352486/jbb_2014-3(2)-pages_133-139.pdf |
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