Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations
Tissue engineered scaffolds for adipose restoration/repair has significantly evolved in recent years. Patients requiring soft tissue reconstruction, caused by defects or pathology, require biomaterials that will restore void volume with new functional tissue. The gold standard of autologous fat graf...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2018.00507/full |
| _version_ | 1828240094047240192 |
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| author | Christopher M. Mahoney Cayla Imbarlina Cecelia C. Yates Cecelia C. Yates Cecelia C. Yates Kacey G. Marra Kacey G. Marra Kacey G. Marra |
| author_facet | Christopher M. Mahoney Cayla Imbarlina Cecelia C. Yates Cecelia C. Yates Cecelia C. Yates Kacey G. Marra Kacey G. Marra Kacey G. Marra |
| author_sort | Christopher M. Mahoney |
| collection | DOAJ |
| description | Tissue engineered scaffolds for adipose restoration/repair has significantly evolved in recent years. Patients requiring soft tissue reconstruction, caused by defects or pathology, require biomaterials that will restore void volume with new functional tissue. The gold standard of autologous fat grafting (AFG) is not a reliable option. This review focuses on the latest therapeutic strategies for the treatment of adipose tissue defects using biomolecule formulations and delivery, and specifically engineered biomaterials. Additionally, the clinical need for reliable off-the-shelf therapies, animal models, and challenges facing current technologies are discussed. |
| first_indexed | 2024-04-12T21:34:13Z |
| format | Article |
| id | doaj.art-2401afbc24f34491b9fa2f2af92f7b96 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T21:34:13Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2401afbc24f34491b9fa2f2af92f7b962022-12-22T03:15:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122018-05-01910.3389/fphar.2018.00507342013Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule FormulationsChristopher M. Mahoney0Cayla Imbarlina1Cecelia C. Yates2Cecelia C. Yates3Cecelia C. Yates4Kacey G. Marra5Kacey G. Marra6Kacey G. Marra7Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Biology, Carlow University, Pittsburgh, PA, United StatesDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Health Promotion and Development, School of Nursing, University of Pittsburgh, Pittsburgh, PA, United StatesMcGowan Institute for Regenerative Medicine, Pittsburgh, PA, United StatesDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United StatesMcGowan Institute for Regenerative Medicine, Pittsburgh, PA, United StatesDepartment of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, United StatesTissue engineered scaffolds for adipose restoration/repair has significantly evolved in recent years. Patients requiring soft tissue reconstruction, caused by defects or pathology, require biomaterials that will restore void volume with new functional tissue. The gold standard of autologous fat grafting (AFG) is not a reliable option. This review focuses on the latest therapeutic strategies for the treatment of adipose tissue defects using biomolecule formulations and delivery, and specifically engineered biomaterials. Additionally, the clinical need for reliable off-the-shelf therapies, animal models, and challenges facing current technologies are discussed.http://journal.frontiersin.org/article/10.3389/fphar.2018.00507/fullmicrospheresadipose-derived stem cellssoft tissue defectsadipose tissue restorationadipogenic factors |
| spellingShingle | Christopher M. Mahoney Cayla Imbarlina Cecelia C. Yates Cecelia C. Yates Cecelia C. Yates Kacey G. Marra Kacey G. Marra Kacey G. Marra Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations Frontiers in Pharmacology microspheres adipose-derived stem cells soft tissue defects adipose tissue restoration adipogenic factors |
| title | Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations |
| title_full | Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations |
| title_fullStr | Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations |
| title_full_unstemmed | Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations |
| title_short | Current Therapeutic Strategies for Adipose Tissue Defects/Repair Using Engineered Biomaterials and Biomolecule Formulations |
| title_sort | current therapeutic strategies for adipose tissue defects repair using engineered biomaterials and biomolecule formulations |
| topic | microspheres adipose-derived stem cells soft tissue defects adipose tissue restoration adipogenic factors |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2018.00507/full |
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