The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress

The CDK-PLK1 axis targets the DNA damage checkpoint sensor protein RAD9 to promote cell proliferation and tolerance to genotoxic stress

Genotoxic stress causes proliferating cells to activate the DNA damage checkpoint, to assist DNA damage recovery by slowing cell cycle progression. Thus, to drive proliferation, cells must tolerate DNA damage and suppress the checkpoint response. However, the mechanism underlying this negative regul...

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Bibliographic Details
Main Authors: Takeshi Wakida, Masae Ikura, Kenji Kuriya, Shinji Ito, Yoshiharu Shiroiwa, Toshiyuki Habu, Takuo Kawamoto, Katsuzumi Okumura, Tsuyoshi Ikura, Kanji Furuya
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
U2OS
HEK293
culture cell
Online Access:https://elifesciences.org/articles/29953

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