Metabolic reprogramming in cervical cancer and metabolomics perspectives
Abstract Cumulative studies have shown that metabolic reprogramming is a hallmark of malignant tumors. The emergence of technological advances, such as omics studies, has strongly contributed to the knowledge of cancer metabolism. Cervical cancer is among the most common cancers in women worldwide....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-10-01
|
| Series: | Nutrition & Metabolism |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12986-021-00615-7 |
| _version_ | 1819024874929127424 |
|---|---|
| author | Boning Li Long Sui |
| author_facet | Boning Li Long Sui |
| author_sort | Boning Li |
| collection | DOAJ |
| description | Abstract Cumulative studies have shown that metabolic reprogramming is a hallmark of malignant tumors. The emergence of technological advances, such as omics studies, has strongly contributed to the knowledge of cancer metabolism. Cervical cancer is among the most common cancers in women worldwide. Because cervical cancer is a virus-associated cancer and can exist in a precancerous state for years, investigations targeting the metabolic phenotypes of cervical cancer will enhance our understanding of the interference of viruses on host cells and the progression of cervical carcinogenesis. The purpose of this review was to illustrate metabolic perturbations in cervical cancer, the role that human papillomavirus (HPV) plays in remodeling cervical cell metabolism and recent approaches toward application of metabolomics in cervical disease research. Cervical cancer displays typical cancer metabolic profiles, including glycolytic switching, high lactate levels, lipid accumulation and abnormal kynurenine/tryptophan levels. HPV, at least in part, contributes to these alterations. Furthermore, emerging metabolomics data provide global information on the metabolic traits of cervical diseases and may aid in the discovery of biomarkers for diagnosis and therapy. |
| first_indexed | 2024-12-21T05:01:44Z |
| format | Article |
| id | doaj.art-2402e1a14b6942f59a8e9f69be0fe0c0 |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-12-21T05:01:44Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-2402e1a14b6942f59a8e9f69be0fe0c02022-12-21T19:15:14ZengBMCNutrition & Metabolism1743-70752021-10-0118111410.1186/s12986-021-00615-7Metabolic reprogramming in cervical cancer and metabolomics perspectivesBoning Li0Long Sui1Obstetrics and Gynecology Hospital, Fudan UniversityObstetrics and Gynecology Hospital, Fudan UniversityAbstract Cumulative studies have shown that metabolic reprogramming is a hallmark of malignant tumors. The emergence of technological advances, such as omics studies, has strongly contributed to the knowledge of cancer metabolism. Cervical cancer is among the most common cancers in women worldwide. Because cervical cancer is a virus-associated cancer and can exist in a precancerous state for years, investigations targeting the metabolic phenotypes of cervical cancer will enhance our understanding of the interference of viruses on host cells and the progression of cervical carcinogenesis. The purpose of this review was to illustrate metabolic perturbations in cervical cancer, the role that human papillomavirus (HPV) plays in remodeling cervical cell metabolism and recent approaches toward application of metabolomics in cervical disease research. Cervical cancer displays typical cancer metabolic profiles, including glycolytic switching, high lactate levels, lipid accumulation and abnormal kynurenine/tryptophan levels. HPV, at least in part, contributes to these alterations. Furthermore, emerging metabolomics data provide global information on the metabolic traits of cervical diseases and may aid in the discovery of biomarkers for diagnosis and therapy.https://doi.org/10.1186/s12986-021-00615-7Cervical cancerHPVp53MetabolomicsWarburg effect |
| spellingShingle | Boning Li Long Sui Metabolic reprogramming in cervical cancer and metabolomics perspectives Nutrition & Metabolism Cervical cancer HPV p53 Metabolomics Warburg effect |
| title | Metabolic reprogramming in cervical cancer and metabolomics perspectives |
| title_full | Metabolic reprogramming in cervical cancer and metabolomics perspectives |
| title_fullStr | Metabolic reprogramming in cervical cancer and metabolomics perspectives |
| title_full_unstemmed | Metabolic reprogramming in cervical cancer and metabolomics perspectives |
| title_short | Metabolic reprogramming in cervical cancer and metabolomics perspectives |
| title_sort | metabolic reprogramming in cervical cancer and metabolomics perspectives |
| topic | Cervical cancer HPV p53 Metabolomics Warburg effect |
| url | https://doi.org/10.1186/s12986-021-00615-7 |
| work_keys_str_mv | AT boningli metabolicreprogrammingincervicalcancerandmetabolomicsperspectives AT longsui metabolicreprogrammingincervicalcancerandmetabolomicsperspectives |