Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization
Curcumin, a naturally occurring lipophilic molecule can exert multiple and diverse bioactivities. However, its limited aqueous solubility and extensive presystemic metabolism restrict its bioavailability. Curcumin phytosomes were prepared by a simple solvent evaporation method where free flowing pow...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2015-09-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2015-0029 |
| _version_ | 1826843097476104192 |
|---|---|
| author | Allam Ahmed N. Komeil Ibrahim A. Abdallah Ossama Y. |
| author_facet | Allam Ahmed N. Komeil Ibrahim A. Abdallah Ossama Y. |
| author_sort | Allam Ahmed N. |
| collection | DOAJ |
| description | Curcumin, a naturally occurring lipophilic molecule can exert multiple and diverse bioactivities. However, its limited aqueous solubility and extensive presystemic metabolism restrict its bioavailability. Curcumin phytosomes were prepared by a simple solvent evaporation method where free flowing powder was obtained in addition to a newly developed semisolid formulation to increase curcumin content in softgels. Phytosomal powder was characterized in terms of drug content and zeta potential. Thirteen different softgel formulations were developed using oils such as Miglyol 812, castor oil and oleic acid, a hydrophilic vehicle such as PEG 400 and bioactive surfactants such as Cremophor EL and KLS P 124. Selected formulations were characterized in terms of curcumin in vitro dissolution. TEM analysis revealed good stability and a spherical, self-closed structure of curcumin phytosomes in complex formulations. Stability studies of chosen formulations prepared using the hydrophilic vehicle revealed a stable curcumin dissolution pattern. In contrast, a dramatic decrease in curcumin dissolution was observed in case of phytosomes formulated in oily vehicles. |
| first_indexed | 2024-12-17T06:44:33Z |
| format | Article |
| id | doaj.art-24043eb5b938433e9fba18bf4c4a548e |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2025-02-16T13:35:40Z |
| publishDate | 2015-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-24043eb5b938433e9fba18bf4c4a548e2025-02-02T11:59:26ZengSciendoActa Pharmaceutica1846-95582015-09-0165328529710.1515/acph-2015-0029acph-2015-0029Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterizationAllam Ahmed N.0Komeil Ibrahim A.1Abdallah Ossama Y.2Faculty of Pharmacy, University of Alexandria, EgyptMedizen Pharmaceutical Industries, Alexandria, EgyptFaculty of Pharmacy, University of Alexandria, EgyptCurcumin, a naturally occurring lipophilic molecule can exert multiple and diverse bioactivities. However, its limited aqueous solubility and extensive presystemic metabolism restrict its bioavailability. Curcumin phytosomes were prepared by a simple solvent evaporation method where free flowing powder was obtained in addition to a newly developed semisolid formulation to increase curcumin content in softgels. Phytosomal powder was characterized in terms of drug content and zeta potential. Thirteen different softgel formulations were developed using oils such as Miglyol 812, castor oil and oleic acid, a hydrophilic vehicle such as PEG 400 and bioactive surfactants such as Cremophor EL and KLS P 124. Selected formulations were characterized in terms of curcumin in vitro dissolution. TEM analysis revealed good stability and a spherical, self-closed structure of curcumin phytosomes in complex formulations. Stability studies of chosen formulations prepared using the hydrophilic vehicle revealed a stable curcumin dissolution pattern. In contrast, a dramatic decrease in curcumin dissolution was observed in case of phytosomes formulated in oily vehicles.https://doi.org/10.1515/acph-2015-0029curcuminphospholipidphytosomesbioavailabilitylipidssoftgels |
| spellingShingle | Allam Ahmed N. Komeil Ibrahim A. Abdallah Ossama Y. Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization Acta Pharmaceutica curcumin phospholipid phytosomes bioavailability lipids softgels |
| title | Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization |
| title_full | Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization |
| title_fullStr | Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization |
| title_full_unstemmed | Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization |
| title_short | Curcumin phytosomal softgel formulation: Development, optimization and physicochemical characterization |
| title_sort | curcumin phytosomal softgel formulation development optimization and physicochemical characterization |
| topic | curcumin phospholipid phytosomes bioavailability lipids softgels |
| url | https://doi.org/10.1515/acph-2015-0029 |
| work_keys_str_mv | AT allamahmedn curcuminphytosomalsoftgelformulationdevelopmentoptimizationandphysicochemicalcharacterization AT komeilibrahima curcuminphytosomalsoftgelformulationdevelopmentoptimizationandphysicochemicalcharacterization AT abdallahossamay curcuminphytosomalsoftgelformulationdevelopmentoptimizationandphysicochemicalcharacterization |