2B4-SAP signaling is required for the priming of naive CD8+ T cells by antigen-expressing B cells and B lymphoma cells

2B4-SAP signaling is required for the priming of naive CD8+ T cells by antigen-expressing B cells and B lymphoma cells

Mutations in SH2D1A gene that encodes SAP (SLAM-associated protein) result in X-linked lymphoproliferative disease (XLP), a rare primary immunodeficiency disease defined by exquisite sensitivity to the B-lymphotropic Epstein–Barr virus (EBV) and B cell lymphomas. However, the precise mechanism of ho...

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Bibliographic Details
Main Authors: Yu-Hsuan Huang, Kevin Tsai, Sara Y. Tan, Sohyeong Kang, Mandy L. Ford, Kenneth W. Harder, John J. Priatel
Format: Article
Language:English
Published: Taylor & Francis Group 2017-02-01
Series:OncoImmunology
Subjects:
antigen-presenting cells
b cells
b cell lymphoma
cd8+ t cells
epstein–barr virus
immune deficiency
slam-associated protein
slam family receptors
t cell receptor
x-linked proliferative disease
Online Access:http://dx.doi.org/10.1080/2162402X.2016.1267094

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