Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages
Lymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family of non-circulating lymphocytes have been iden...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02104/full |
| _version_ | 1828395592696463360 |
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| author | Chun Chou Ming O. Li |
| author_facet | Chun Chou Ming O. Li |
| author_sort | Chun Chou |
| collection | DOAJ |
| description | Lymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family of non-circulating lymphocytes have been identified. These include innate lymphocytes, innate-like T cells and a subset of conventional T cells. Spanning the innate-adaptive spectrum, these tissue-resident lymphocytes carry out specialized functions and cross-talk with other immune cell types to maintain tissue integrity and homeostasis both at the steady state and during pathological conditions. In this review, we provide an overview of the heterogeneous tissue-resident lymphocyte populations, discuss their development, and highlight their functions both in the context of microbial infection and cancer. |
| first_indexed | 2024-12-10T08:15:51Z |
| format | Article |
| id | doaj.art-240818fb490a4e1ab4904adcffd50080 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T08:15:51Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-240818fb490a4e1ab4904adcffd500802022-12-22T01:56:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02104399246Tissue-Resident Lymphocytes Across Innate and Adaptive LineagesChun ChouMing O. LiLymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family of non-circulating lymphocytes have been identified. These include innate lymphocytes, innate-like T cells and a subset of conventional T cells. Spanning the innate-adaptive spectrum, these tissue-resident lymphocytes carry out specialized functions and cross-talk with other immune cell types to maintain tissue integrity and homeostasis both at the steady state and during pathological conditions. In this review, we provide an overview of the heterogeneous tissue-resident lymphocyte populations, discuss their development, and highlight their functions both in the context of microbial infection and cancer.https://www.frontiersin.org/article/10.3389/fimmu.2018.02104/fulltissue residentinnate lymphocyteinnate-like T cellsconventional T cellscancerinfection |
| spellingShingle | Chun Chou Ming O. Li Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages Frontiers in Immunology tissue resident innate lymphocyte innate-like T cells conventional T cells cancer infection |
| title | Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages |
| title_full | Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages |
| title_fullStr | Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages |
| title_full_unstemmed | Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages |
| title_short | Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages |
| title_sort | tissue resident lymphocytes across innate and adaptive lineages |
| topic | tissue resident innate lymphocyte innate-like T cells conventional T cells cancer infection |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02104/full |
| work_keys_str_mv | AT chunchou tissueresidentlymphocytesacrossinnateandadaptivelineages AT mingoli tissueresidentlymphocytesacrossinnateandadaptivelineages |