GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma
Glutathione peroxidase 2 has important role of tumor progression in lots of carcinomas, yet little is known about the prognosis of glutathione peroxidase 2 in hepatocellular carcinoma. Glutathione peroxidase 2 expression was assessed by immunohistochemistry in hepatocellular carcinoma tissues. The a...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IOS Press
2017-06-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317700410 |
| _version_ | 1818950103885414400 |
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| author | Ting Liu Xue-feng Kan Charlie Ma Li-li Chen Tian-tian Cheng Zhen-wei Zou Yong Li Feng-jun Cao Wen-jie Zhang Jing Yao Pin-dong Li |
| author_facet | Ting Liu Xue-feng Kan Charlie Ma Li-li Chen Tian-tian Cheng Zhen-wei Zou Yong Li Feng-jun Cao Wen-jie Zhang Jing Yao Pin-dong Li |
| author_sort | Ting Liu |
| collection | DOAJ |
| description | Glutathione peroxidase 2 has important role of tumor progression in lots of carcinomas, yet little is known about the prognosis of glutathione peroxidase 2 in hepatocellular carcinoma. Glutathione peroxidase 2 expression was assessed by immunohistochemistry in hepatocellular carcinoma tissues. The association between glutathione peroxidase 2 expression with clinicopathological/prognostic value was examined. Glutathione peroxidase 2 overexpression was correlated with alpha-fetoprotein level, larger tumor, BCLC stage, and tumor recurrence. Kaplan–Meier analysis showed that glutathione peroxidase 2 was an independent predictor for overall survival and time to recurrence. glutathione peroxidase 2 overexpression was correlated with poor prognosis in patient subgroups stratified by tumor size, differentiation, tumor–node–metastasis, and BCLC stage. Moreover, stratified analysis showed that tumor–node–metastasis stage-I patients with high glutathione peroxidase 2 expression had poor prognosis than those with low glutathione peroxidase 2 expression. Additionally, combination of glutathione peroxidase 2 and serum alpha-fetoprotein was correlated with prognosis in hepatocellular carcinoma. In conclusion, glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients. |
| first_indexed | 2024-12-20T09:13:16Z |
| format | Article |
| id | doaj.art-240973768fbc4417a5fbe80e2110e66f |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-20T09:13:16Z |
| publishDate | 2017-06-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-240973768fbc4417a5fbe80e2110e66f2022-12-21T19:45:29ZengIOS PressTumor Biology1423-03802017-06-013910.1177/1010428317700410GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinomaTing Liu0Xue-feng Kan1Charlie Ma2Li-li Chen3Tian-tian Cheng4Zhen-wei Zou5Yong Li6Feng-jun Cao7Wen-jie Zhang8Jing Yao9Pin-dong Li10Department of Infectious Diseases, Institute of Infection and Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaThe Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USAThe Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USAAffiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Renmin Hospital, Hubei University of Medicine, Shiyan, ChinaCancer Center, Renmin Hospital, Hubei University of Medicine, Shiyan, ChinaDepartment of Pathology, Shihezi University School of Medicine, Shihezi, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaGlutathione peroxidase 2 has important role of tumor progression in lots of carcinomas, yet little is known about the prognosis of glutathione peroxidase 2 in hepatocellular carcinoma. Glutathione peroxidase 2 expression was assessed by immunohistochemistry in hepatocellular carcinoma tissues. The association between glutathione peroxidase 2 expression with clinicopathological/prognostic value was examined. Glutathione peroxidase 2 overexpression was correlated with alpha-fetoprotein level, larger tumor, BCLC stage, and tumor recurrence. Kaplan–Meier analysis showed that glutathione peroxidase 2 was an independent predictor for overall survival and time to recurrence. glutathione peroxidase 2 overexpression was correlated with poor prognosis in patient subgroups stratified by tumor size, differentiation, tumor–node–metastasis, and BCLC stage. Moreover, stratified analysis showed that tumor–node–metastasis stage-I patients with high glutathione peroxidase 2 expression had poor prognosis than those with low glutathione peroxidase 2 expression. Additionally, combination of glutathione peroxidase 2 and serum alpha-fetoprotein was correlated with prognosis in hepatocellular carcinoma. In conclusion, glutathione peroxidase 2 overexpression contributes to poor prognosis of hepatocellular carcinoma patients and helps to identify the high-risk hepatocellular carcinoma patients.https://doi.org/10.1177/1010428317700410 |
| spellingShingle | Ting Liu Xue-feng Kan Charlie Ma Li-li Chen Tian-tian Cheng Zhen-wei Zou Yong Li Feng-jun Cao Wen-jie Zhang Jing Yao Pin-dong Li GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma Tumor Biology |
| title | GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma |
| title_full | GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma |
| title_fullStr | GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma |
| title_full_unstemmed | GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma |
| title_short | GPX2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma |
| title_sort | gpx2 overexpression indicates poor prognosis in patients with hepatocellular carcinoma |
| url | https://doi.org/10.1177/1010428317700410 |
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