Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease
<p>Abstract</p> <p>Chronic obstructive pulmonary disease (COPD) is a treatable and preventable disease state, characterised by progressive airflow limitation that is not fully reversible. Although COPD is primarily a disease of the lungs there is now an appreciation that many of th...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-04-01
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| Series: | Respiratory Research |
| Online Access: | http://respiratory-research.com/content/10/1/29 |
| _version_ | 1818212487185563648 |
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| author | Corne Jonathan Metcalf Rebecca Lunt Elizabeth AM Urbanowicz Richard A Richens Joanna L Fairclough Lucy O'Shea Paul |
| author_facet | Corne Jonathan Metcalf Rebecca Lunt Elizabeth AM Urbanowicz Richard A Richens Joanna L Fairclough Lucy O'Shea Paul |
| author_sort | Corne Jonathan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Chronic obstructive pulmonary disease (COPD) is a treatable and preventable disease state, characterised by progressive airflow limitation that is not fully reversible. Although COPD is primarily a disease of the lungs there is now an appreciation that many of the manifestations of disease are outside the lung, leading to the notion that COPD is a systemic disease. Currently, diagnosis of COPD relies on largely descriptive measures to enable classification, such as symptoms and lung function. Here the limitations of existing diagnostic strategies of COPD are discussed and systems biology approaches to diagnosis that build upon current molecular knowledge of the disease are described. These approaches rely on new 'label-free' sensing technologies, such as high-throughput surface plasmon resonance (SPR), that we also describe.</p> |
| first_indexed | 2024-12-12T05:49:10Z |
| format | Article |
| id | doaj.art-240e9540cd634fe5ab6fd206a65d0457 |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-12T05:49:10Z |
| publishDate | 2009-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-240e9540cd634fe5ab6fd206a65d04572022-12-22T00:35:43ZengBMCRespiratory Research1465-99212009-04-011012910.1186/1465-9921-10-29Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary diseaseCorne JonathanMetcalf RebeccaLunt Elizabeth AMUrbanowicz Richard ARichens Joanna LFairclough LucyO'Shea Paul<p>Abstract</p> <p>Chronic obstructive pulmonary disease (COPD) is a treatable and preventable disease state, characterised by progressive airflow limitation that is not fully reversible. Although COPD is primarily a disease of the lungs there is now an appreciation that many of the manifestations of disease are outside the lung, leading to the notion that COPD is a systemic disease. Currently, diagnosis of COPD relies on largely descriptive measures to enable classification, such as symptoms and lung function. Here the limitations of existing diagnostic strategies of COPD are discussed and systems biology approaches to diagnosis that build upon current molecular knowledge of the disease are described. These approaches rely on new 'label-free' sensing technologies, such as high-throughput surface plasmon resonance (SPR), that we also describe.</p>http://respiratory-research.com/content/10/1/29 |
| spellingShingle | Corne Jonathan Metcalf Rebecca Lunt Elizabeth AM Urbanowicz Richard A Richens Joanna L Fairclough Lucy O'Shea Paul Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease Respiratory Research |
| title | Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease |
| title_full | Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease |
| title_fullStr | Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease |
| title_full_unstemmed | Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease |
| title_short | Systems biology coupled with label-free high-throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease |
| title_sort | systems biology coupled with label free high throughput detection as a novel approach for diagnosis of chronic obstructive pulmonary disease |
| url | http://respiratory-research.com/content/10/1/29 |
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