Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of Hypomagnesemia
Hypomagnesemia was historically prevalent in individuals with type 1 diabetes mellitus (T1DM), but contemporary results indicate an incidence comparable to that in the general population, likely due to improved treatment in recent decades, resulting in better glycemic control. However, a recent stud...
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MDPI AG
2023-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/21/15683 |
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| author | Kaj Vaughan Sullivan Yasmina Assantuh Rosa Grigoryan Marta Costas-Rodríguez Eduardo Bolea-Fernandez Bruno Lapauw Steven Van Laecke Frank Vanhaecke |
| author_facet | Kaj Vaughan Sullivan Yasmina Assantuh Rosa Grigoryan Marta Costas-Rodríguez Eduardo Bolea-Fernandez Bruno Lapauw Steven Van Laecke Frank Vanhaecke |
| author_sort | Kaj Vaughan Sullivan |
| collection | DOAJ |
| description | Hypomagnesemia was historically prevalent in individuals with type 1 diabetes mellitus (T1DM), but contemporary results indicate an incidence comparable to that in the general population, likely due to improved treatment in recent decades, resulting in better glycemic control. However, a recent study found a significant difference between the serum Mg isotopic composition of T1DM individuals and controls, indicating that disruptions to Mg homeostasis persist. Significant deviations were also found in samples taken one year apart. To investigate whether the temporal variability in serum Mg isotopic composition is linked to the transient impact of administered insulin, Mg isotope ratios were determined in serum from 15 T1DM individuals before and one hour after insulin injection/meal consumption using multi-collector inductively coupled plasma-mass spectrometry. Consistent with results of the previous study, significant difference in the serum Mg isotopic composition was found between T1DM individuals and 10 sex-matched controls. However, the average difference between pre- and post-insulin injection/meal T1DM samples of 0.05 ± 0.13‰ (1SD) was not significant. No difference was observed for controls before (−0.12 ± 0.16‰) and after the meal (−0.10 ± 0.13‰) either, suggesting a lack of a postprandial Mg isotopic response within one hour of food consumption, and that the timing of the most recent meal may not require controlling for when determining serum Mg isotopic composition. |
| first_indexed | 2024-03-11T11:28:05Z |
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| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T11:28:05Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-24103247daba4afd9e5724c6125a8dd82023-11-10T15:04:53ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-10-0124211568310.3390/ijms242115683Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of HypomagnesemiaKaj Vaughan Sullivan0Yasmina Assantuh1Rosa Grigoryan2Marta Costas-Rodríguez3Eduardo Bolea-Fernandez4Bruno Lapauw5Steven Van Laecke6Frank Vanhaecke7Atomic and Mass Spectrometry—A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, BelgiumAtomic and Mass Spectrometry—A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, BelgiumThe Isotoparium, Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USAAtomic and Mass Spectrometry—A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, BelgiumAtomic and Mass Spectrometry—A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, BelgiumDepartment of Endocrinology, Ghent University Hospital, 9000 Ghent, BelgiumRenal Division, Department of Internal Medicine and Pediatrics, Ghent University Hospital, 9000 Ghent, BelgiumAtomic and Mass Spectrometry—A&MS Research Unit, Department of Chemistry, Ghent University, 9000 Ghent, BelgiumHypomagnesemia was historically prevalent in individuals with type 1 diabetes mellitus (T1DM), but contemporary results indicate an incidence comparable to that in the general population, likely due to improved treatment in recent decades, resulting in better glycemic control. However, a recent study found a significant difference between the serum Mg isotopic composition of T1DM individuals and controls, indicating that disruptions to Mg homeostasis persist. Significant deviations were also found in samples taken one year apart. To investigate whether the temporal variability in serum Mg isotopic composition is linked to the transient impact of administered insulin, Mg isotope ratios were determined in serum from 15 T1DM individuals before and one hour after insulin injection/meal consumption using multi-collector inductively coupled plasma-mass spectrometry. Consistent with results of the previous study, significant difference in the serum Mg isotopic composition was found between T1DM individuals and 10 sex-matched controls. However, the average difference between pre- and post-insulin injection/meal T1DM samples of 0.05 ± 0.13‰ (1SD) was not significant. No difference was observed for controls before (−0.12 ± 0.16‰) and after the meal (−0.10 ± 0.13‰) either, suggesting a lack of a postprandial Mg isotopic response within one hour of food consumption, and that the timing of the most recent meal may not require controlling for when determining serum Mg isotopic composition.https://www.mdpi.com/1422-0067/24/21/15683magnesiumtype 1 diabetes mellitusMC-ICP-MShypomagnesemiastable isotope ratios |
| spellingShingle | Kaj Vaughan Sullivan Yasmina Assantuh Rosa Grigoryan Marta Costas-Rodríguez Eduardo Bolea-Fernandez Bruno Lapauw Steven Van Laecke Frank Vanhaecke Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of Hypomagnesemia International Journal of Molecular Sciences magnesium type 1 diabetes mellitus MC-ICP-MS hypomagnesemia stable isotope ratios |
| title | Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of Hypomagnesemia |
| title_full | Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of Hypomagnesemia |
| title_fullStr | Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of Hypomagnesemia |
| title_full_unstemmed | Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of Hypomagnesemia |
| title_short | Serum Mg Isotopic Composition Reveals That Mg Dyshomeostasis Remains in Type 1 Diabetes despite the Resolution of Hypomagnesemia |
| title_sort | serum mg isotopic composition reveals that mg dyshomeostasis remains in type 1 diabetes despite the resolution of hypomagnesemia |
| topic | magnesium type 1 diabetes mellitus MC-ICP-MS hypomagnesemia stable isotope ratios |
| url | https://www.mdpi.com/1422-0067/24/21/15683 |
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