Milk-alkali syndrome and tacrolimus metabolism
Chronic immunosuppressive therapy is critical to all transplant patients to help prevent rejection, chronic injury and loss of allograft. Tacrolimus is used as immunosuppression in more than ninety percent of kidney transplant recipients, and requires drug level monitoring. It is known that many pre...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | Transplantation Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451959622000312 |
| _version_ | 1811177666772992000 |
|---|---|
| author | Gurbir Singh Sabrina Lee Meena Parakaal Michelle Hwang Erik L. Lum |
| author_facet | Gurbir Singh Sabrina Lee Meena Parakaal Michelle Hwang Erik L. Lum |
| author_sort | Gurbir Singh |
| collection | DOAJ |
| description | Chronic immunosuppressive therapy is critical to all transplant patients to help prevent rejection, chronic injury and loss of allograft. Tacrolimus is used as immunosuppression in more than ninety percent of kidney transplant recipients, and requires drug level monitoring. It is known that many prescribed medications can alter tacrolimus metabolism and lead to unpredictable levels that may expose patients to the above-mentioned complications. However, the use of over-the-counter medications is often overlooked. Here, we present a case report in which over-the-counter calcium carbonate significantly affected the patient's tacrolimus metabolism leading to unpredictable levels. |
| first_indexed | 2024-04-11T06:04:57Z |
| format | Article |
| id | doaj.art-2410cb7a95904084b426431156e5fc8f |
| institution | Directory Open Access Journal |
| issn | 2451-9596 |
| language | English |
| last_indexed | 2024-04-11T06:04:57Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Transplantation Reports |
| spelling | doaj.art-2410cb7a95904084b426431156e5fc8f2022-12-22T04:41:31ZengElsevierTransplantation Reports2451-95962022-12-0174100123Milk-alkali syndrome and tacrolimus metabolismGurbir Singh0Sabrina Lee1Meena Parakaal2Michelle Hwang3Erik L. Lum4Department of Medicine, Division Nephrology, David Geffen School of Medicine, University of California Los Angeles, 200 Medical Plaza, Ste 565, Los Angeles, CA 90095, United StatesDepartment of Pharmaceutical Services, Ronald Reagan Medical Center, Los Angeles, United StatesDepartment of Medicine, Division Nephrology, David Geffen School of Medicine, University of California Los Angeles, 200 Medical Plaza, Ste 565, Los Angeles, CA 90095, United StatesDepartment of Medicine, Division Nephrology, David Geffen School of Medicine, University of California Los Angeles, 200 Medical Plaza, Ste 565, Los Angeles, CA 90095, United StatesDepartment of Medicine, Division Nephrology, David Geffen School of Medicine, University of California Los Angeles, 200 Medical Plaza, Ste 565, Los Angeles, CA 90095, United States; Corresponding author.Chronic immunosuppressive therapy is critical to all transplant patients to help prevent rejection, chronic injury and loss of allograft. Tacrolimus is used as immunosuppression in more than ninety percent of kidney transplant recipients, and requires drug level monitoring. It is known that many prescribed medications can alter tacrolimus metabolism and lead to unpredictable levels that may expose patients to the above-mentioned complications. However, the use of over-the-counter medications is often overlooked. Here, we present a case report in which over-the-counter calcium carbonate significantly affected the patient's tacrolimus metabolism leading to unpredictable levels.http://www.sciencedirect.com/science/article/pii/S2451959622000312TransplantationTacrolimusMetabolismMilk alkali syndrome immunosuppression |
| spellingShingle | Gurbir Singh Sabrina Lee Meena Parakaal Michelle Hwang Erik L. Lum Milk-alkali syndrome and tacrolimus metabolism Transplantation Reports Transplantation Tacrolimus Metabolism Milk alkali syndrome immunosuppression |
| title | Milk-alkali syndrome and tacrolimus metabolism |
| title_full | Milk-alkali syndrome and tacrolimus metabolism |
| title_fullStr | Milk-alkali syndrome and tacrolimus metabolism |
| title_full_unstemmed | Milk-alkali syndrome and tacrolimus metabolism |
| title_short | Milk-alkali syndrome and tacrolimus metabolism |
| title_sort | milk alkali syndrome and tacrolimus metabolism |
| topic | Transplantation Tacrolimus Metabolism Milk alkali syndrome immunosuppression |
| url | http://www.sciencedirect.com/science/article/pii/S2451959622000312 |
| work_keys_str_mv | AT gurbirsingh milkalkalisyndromeandtacrolimusmetabolism AT sabrinalee milkalkalisyndromeandtacrolimusmetabolism AT meenaparakaal milkalkalisyndromeandtacrolimusmetabolism AT michellehwang milkalkalisyndromeandtacrolimusmetabolism AT erikllum milkalkalisyndromeandtacrolimusmetabolism |