DNA damage response alterations in clear cell renal cell carcinoma: clinical, molecular, and prognostic implications

DNA damage response alterations in clear cell renal cell carcinoma: clinical, molecular, and prognostic implications

Abstract Background DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic responses. Nonetheless, the characteristics and significance of DDR alterations in clear cell renal cell carcinoma (ccRCC) remain undefined. This study aimed to explore the predictive role, molecu...

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Bibliographic Details
Main Authors: Xiao Jing, Xiangcheng Qin, Hao Liu, Huanhuan Liu, Huina Wang, Jiayue Qin, Yanui Zhang, Shanbo Cao, Xiaodong Fan
Format: Article
Language:English
Published: BMC 2024-02-01
Series:European Journal of Medical Research
Subjects:
Clear cell renal cell carcinoma (ccRCC)
DNA damage repair (DDR)
Prognosis
Tumor microenvironment
Tumor mutational burden (TMB)
Online Access:https://doi.org/10.1186/s40001-024-01678-x

Internet

https://doi.org/10.1186/s40001-024-01678-x

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