Serum Antibody Activity against Poly-N-Acetyl Glucosamine (PNAG), but Not PNAG Vaccination Status, Is Associated with Protecting Newborn Foals against Intrabronchial Infection with Rhodococcus equi

Serum Antibody Activity against Poly-N-Acetyl Glucosamine (PNAG), but Not PNAG Vaccination Status, Is Associated with Protecting Newborn Foals against Intrabronchial Infection with Rhodococcus equi

ABSTRACT Rhodococcus equi is a prevalent cause of pneumonia in foals worldwide. Our laboratory has demonstrated that vaccination against the surface polysaccharide β-1→6-poly-N-acetylglucosamine (PNAG) protects foals against intrabronchial infection with R. equi when challenged at age 28 days. Howev...

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Bibliographic Details
Main Authors: Noah D. Cohen, Susanne K. Kahn, Colette Cywes-Bentley, Sophia Ramirez-Cortez, Amanda E. Schuckert, Mariana Vinacur, Angela I. Bordin, Gerald B. Pier
Format: Article
Language:English
Published: American Society for Microbiology 2021-09-01
Series:Microbiology Spectrum
Subjects:
foal
poly-N-acetyl glucosamine
Rhodococcus equi
antibody
pneumonia
veterinary vaccine development
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00638-21

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