The role of mechanically sensitive ion channel Piezo1 in bone remodeling
Piezo1 (2010) was identified as a mechanically activated cation channel capable of sensing various physical forces, such as tension, osmotic pressure, and shear force. Piezo1 mediates mechanosensory transduction in different organs and tissues, including its role in maintaining bone homeostasis. Thi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1342149/full |
| _version_ | 1797320541043949568 |
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| author | Yugui Du Bowen Xu Quiying Li Chuhan Peng Kai Yang |
| author_facet | Yugui Du Bowen Xu Quiying Li Chuhan Peng Kai Yang |
| author_sort | Yugui Du |
| collection | DOAJ |
| description | Piezo1 (2010) was identified as a mechanically activated cation channel capable of sensing various physical forces, such as tension, osmotic pressure, and shear force. Piezo1 mediates mechanosensory transduction in different organs and tissues, including its role in maintaining bone homeostasis. This review aimed to summarize the function and possible mechanism of Piezo1 in the mechanical receptor cells in bone tissue. We found that it is a potential therapeutic target for the treatment of bone diseases. |
| first_indexed | 2024-03-08T04:44:32Z |
| format | Article |
| id | doaj.art-24163c7703484933bf8e9872379e67f9 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-08T04:44:32Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-24163c7703484933bf8e9872379e67f92024-02-08T11:30:11ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-02-011210.3389/fbioe.2024.13421491342149The role of mechanically sensitive ion channel Piezo1 in bone remodelingYugui DuBowen XuQuiying LiChuhan PengKai YangPiezo1 (2010) was identified as a mechanically activated cation channel capable of sensing various physical forces, such as tension, osmotic pressure, and shear force. Piezo1 mediates mechanosensory transduction in different organs and tissues, including its role in maintaining bone homeostasis. This review aimed to summarize the function and possible mechanism of Piezo1 in the mechanical receptor cells in bone tissue. We found that it is a potential therapeutic target for the treatment of bone diseases.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1342149/fullPiezo1bone remodelingosteoblastsosteoclastsmechanical force |
| spellingShingle | Yugui Du Bowen Xu Quiying Li Chuhan Peng Kai Yang The role of mechanically sensitive ion channel Piezo1 in bone remodeling Frontiers in Bioengineering and Biotechnology Piezo1 bone remodeling osteoblasts osteoclasts mechanical force |
| title | The role of mechanically sensitive ion channel Piezo1 in bone remodeling |
| title_full | The role of mechanically sensitive ion channel Piezo1 in bone remodeling |
| title_fullStr | The role of mechanically sensitive ion channel Piezo1 in bone remodeling |
| title_full_unstemmed | The role of mechanically sensitive ion channel Piezo1 in bone remodeling |
| title_short | The role of mechanically sensitive ion channel Piezo1 in bone remodeling |
| title_sort | role of mechanically sensitive ion channel piezo1 in bone remodeling |
| topic | Piezo1 bone remodeling osteoblasts osteoclasts mechanical force |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1342149/full |
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