The association of relapsing polychondritis and spondylarthritis – three case reports
Background. Relapsing polychondritis (RP) is characterized by recurrent episodes of progressive inflammation that lead to the destruction of cartilaginous structures. The etiopathogenesis is not fully elucidated, but it seems to be an immunemediated mechanism directed against type 2 collagen. Case...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2023-09-01
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| Series: | Romanian Journal of Rheumatology |
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| Online Access: | https://rjr.com.ro/articles/2023.3/RJR_2023_3_Art-08.pdf |
| _version_ | 1797353792447971328 |
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| author | Eleonora Alina Dragomir-Lica Denisa Elena Moscalu Luminita Enache Claudiu Costinel Popescu Catalin Codreanu |
| author_facet | Eleonora Alina Dragomir-Lica Denisa Elena Moscalu Luminita Enache Claudiu Costinel Popescu Catalin Codreanu |
| author_sort | Eleonora Alina Dragomir-Lica |
| collection | DOAJ |
| description | Background. Relapsing polychondritis (RP) is characterized by recurrent episodes of progressive inflammation that lead to the destruction of cartilaginous structures. The etiopathogenesis is not fully elucidated, but it seems to be an immunemediated mechanism directed against type 2 collagen.
Case reports. We present a series of 3 clinical cases, which associate RP and spondylarthritis – a woman with psoriatic arthritis (PsA) and two men with ankylosing spondylitis (AS). All cases presented with auricular chondritis, which is the emblem of RP. In the PsA case, RP presented typically, with recurrent auricular chondritis, manifested clinically with a cauliflower-like appearance of the ears. In one of the AS cases, a paradoxical immune reaction related to biological therapy was considered in the differential diagnosis of RP. In the other AS case, the patient had a single episode of chondritis, the recurrence of the disease remains to be proved. Conclusions. The diagnosis of RP is usually based on clinical evidence and the elimination of differential diagnoses, since
there is no specific laboratory or imaging test. In 20-30% of cases, RP is associated with other conditions, most frequently with vasculitis, but the association of RP with spondylarthritis is rare. |
| first_indexed | 2024-03-08T13:36:04Z |
| format | Article |
| id | doaj.art-2417189d4d0e4521afb7d0e41203eb1d |
| institution | Directory Open Access Journal |
| issn | 1843-0791 2069-6086 |
| language | English |
| last_indexed | 2024-03-08T13:36:04Z |
| publishDate | 2023-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Rheumatology |
| spelling | doaj.art-2417189d4d0e4521afb7d0e41203eb1d2024-01-16T16:02:31ZengAmaltea Medical Publishing HouseRomanian Journal of Rheumatology1843-07912069-60862023-09-0132312813410.37897/RJR.2023.3.8The association of relapsing polychondritis and spondylarthritis – three case reportsEleonora Alina Dragomir-Lica0Denisa Elena Moscalu1Luminita Enache2Claudiu Costinel Popescu3Catalin Codreanu4Rheumathology Department, “Dr. Ion Stoia” Clinical Centre for Rheumatic Diseases, Bucharest, RomaniaRheumathology Department, “Dr. Ion Stoia” Clinical Centre for Rheumatic Diseases, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaRheumathology Department, “Dr. Ion Stoia” Clinical Centre for Rheumatic Diseases, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaRheumathology Department, “Dr. Ion Stoia” Clinical Centre for Rheumatic Diseases, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaRheumathology Department, “Dr. Ion Stoia” Clinical Centre for Rheumatic Diseases, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaBackground. Relapsing polychondritis (RP) is characterized by recurrent episodes of progressive inflammation that lead to the destruction of cartilaginous structures. The etiopathogenesis is not fully elucidated, but it seems to be an immunemediated mechanism directed against type 2 collagen. Case reports. We present a series of 3 clinical cases, which associate RP and spondylarthritis – a woman with psoriatic arthritis (PsA) and two men with ankylosing spondylitis (AS). All cases presented with auricular chondritis, which is the emblem of RP. In the PsA case, RP presented typically, with recurrent auricular chondritis, manifested clinically with a cauliflower-like appearance of the ears. In one of the AS cases, a paradoxical immune reaction related to biological therapy was considered in the differential diagnosis of RP. In the other AS case, the patient had a single episode of chondritis, the recurrence of the disease remains to be proved. Conclusions. The diagnosis of RP is usually based on clinical evidence and the elimination of differential diagnoses, since there is no specific laboratory or imaging test. In 20-30% of cases, RP is associated with other conditions, most frequently with vasculitis, but the association of RP with spondylarthritis is rare.https://rjr.com.ro/articles/2023.3/RJR_2023_3_Art-08.pdfrelapsing polychondritisankylosing spondylitispsoriatic arthritis |
| spellingShingle | Eleonora Alina Dragomir-Lica Denisa Elena Moscalu Luminita Enache Claudiu Costinel Popescu Catalin Codreanu The association of relapsing polychondritis and spondylarthritis – three case reports Romanian Journal of Rheumatology relapsing polychondritis ankylosing spondylitis psoriatic arthritis |
| title | The association of relapsing polychondritis and spondylarthritis – three case reports |
| title_full | The association of relapsing polychondritis and spondylarthritis – three case reports |
| title_fullStr | The association of relapsing polychondritis and spondylarthritis – three case reports |
| title_full_unstemmed | The association of relapsing polychondritis and spondylarthritis – three case reports |
| title_short | The association of relapsing polychondritis and spondylarthritis – three case reports |
| title_sort | association of relapsing polychondritis and spondylarthritis three case reports |
| topic | relapsing polychondritis ankylosing spondylitis psoriatic arthritis |
| url | https://rjr.com.ro/articles/2023.3/RJR_2023_3_Art-08.pdf |
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