Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications
Yeast particles (YPs) are 3–5 µm hollow and porous microspheres, a byproduct of some food grade yeast (<i>Saccharomyces cerevisiae</i>) extract manufacturing processes. Terpenes can be efficiently encapsulated inside YPs by passive diffusion through the porous cell walls. As previously p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/11/3580 |
| _version_ | 1797492407928881152 |
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| author | Ernesto R. Soto Florentina Rus Gary R. Ostroff |
| author_facet | Ernesto R. Soto Florentina Rus Gary R. Ostroff |
| author_sort | Ernesto R. Soto |
| collection | DOAJ |
| description | Yeast particles (YPs) are 3–5 µm hollow and porous microspheres, a byproduct of some food grade yeast (<i>Saccharomyces cerevisiae</i>) extract manufacturing processes. Terpenes can be efficiently encapsulated inside YPs by passive diffusion through the porous cell walls. As previously published, this YP terpene encapsulation approach has been successfully implemented (1) to develop and commercialize fungicide and nematicide products for agricultural applications, (2) to co-load high potency agrochemical actives dissolved in terpenes or suitable solvents, and (3) to identify YP terpenes with broad-acting anthelmintic activity for potential pharmaceutical applications. These first-generation YP terpene materials were developed with a <2:1 terpene: YP weight ratio. Here we report methods to increase the terpene loading capacity in YPs up to 5:1 terpene: YP weight ratio. Hyper-loaded YP terpenes extend the kinetics of payload release up to three-fold compared to the commercialized YP terpene formulations. Hyper-loaded YP-terpene compositions were further optimized to achieve high terpene storage encapsulation stability from −20 °C to 54 °C. The development of hyper-loaded YP terpenes has a wide range of potential agricultural and pharmaceutical applications with terpenes and other compatible active substances that could benefit from a delivery system with a high payload loading capacity combined with increased payload stability and sustained release properties. |
| first_indexed | 2024-03-10T01:03:21Z |
| format | Article |
| id | doaj.art-241828b536734f4691f80ffc47af3ffb |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T01:03:21Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-241828b536734f4691f80ffc47af3ffb2023-11-23T14:31:05ZengMDPI AGMolecules1420-30492022-06-012711358010.3390/molecules27113580Yeast Particles Hyper-Loaded with Terpenes for Biocide ApplicationsErnesto R. Soto0Florentina Rus1Gary R. Ostroff2Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USAYeast particles (YPs) are 3–5 µm hollow and porous microspheres, a byproduct of some food grade yeast (<i>Saccharomyces cerevisiae</i>) extract manufacturing processes. Terpenes can be efficiently encapsulated inside YPs by passive diffusion through the porous cell walls. As previously published, this YP terpene encapsulation approach has been successfully implemented (1) to develop and commercialize fungicide and nematicide products for agricultural applications, (2) to co-load high potency agrochemical actives dissolved in terpenes or suitable solvents, and (3) to identify YP terpenes with broad-acting anthelmintic activity for potential pharmaceutical applications. These first-generation YP terpene materials were developed with a <2:1 terpene: YP weight ratio. Here we report methods to increase the terpene loading capacity in YPs up to 5:1 terpene: YP weight ratio. Hyper-loaded YP terpenes extend the kinetics of payload release up to three-fold compared to the commercialized YP terpene formulations. Hyper-loaded YP-terpene compositions were further optimized to achieve high terpene storage encapsulation stability from −20 °C to 54 °C. The development of hyper-loaded YP terpenes has a wide range of potential agricultural and pharmaceutical applications with terpenes and other compatible active substances that could benefit from a delivery system with a high payload loading capacity combined with increased payload stability and sustained release properties.https://www.mdpi.com/1420-3049/27/11/3580yeast particlesterpenesmicroencapsulationbiocidecontrolled delivery |
| spellingShingle | Ernesto R. Soto Florentina Rus Gary R. Ostroff Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications Molecules yeast particles terpenes microencapsulation biocide controlled delivery |
| title | Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications |
| title_full | Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications |
| title_fullStr | Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications |
| title_full_unstemmed | Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications |
| title_short | Yeast Particles Hyper-Loaded with Terpenes for Biocide Applications |
| title_sort | yeast particles hyper loaded with terpenes for biocide applications |
| topic | yeast particles terpenes microencapsulation biocide controlled delivery |
| url | https://www.mdpi.com/1420-3049/27/11/3580 |
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