Ubiquitin Ligases in Cholesterol Metabolism
To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players in cholesterol metabolism has been characterized. More and mor...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2014-06-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-171.pdf |
| _version_ | 1811276565766471680 |
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| author | Wei Jiang Bao-Liang Song |
| author_facet | Wei Jiang Bao-Liang Song |
| author_sort | Wei Jiang |
| collection | DOAJ |
| description | To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players in cholesterol metabolism has been characterized. More and more ubiquitin ligases have been identified including gp78, Hrd1, TRC8, TEB4, Fbw7, and inducible degrader of low density lipoprotein receptor. Their working mechanisms and physiological functions are becoming revealed. Here, we summarize the structure, substrates and function of these ubiquitin ligases. Their potential application in drug discovery is also discussed. |
| first_indexed | 2024-04-12T23:58:52Z |
| format | Article |
| id | doaj.art-2418438efa1e474d832c03cfe09b3ce9 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-04-12T23:58:52Z |
| publishDate | 2014-06-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-2418438efa1e474d832c03cfe09b3ce92022-12-22T03:11:24ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872014-06-0138317118010.4093/dmj.2014.38.3.17114617Ubiquitin Ligases in Cholesterol MetabolismWei JiangBao-Liang SongTo maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players in cholesterol metabolism has been characterized. More and more ubiquitin ligases have been identified including gp78, Hrd1, TRC8, TEB4, Fbw7, and inducible degrader of low density lipoprotein receptor. Their working mechanisms and physiological functions are becoming revealed. Here, we summarize the structure, substrates and function of these ubiquitin ligases. Their potential application in drug discovery is also discussed.http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-171.pdfCholesterol metabolismProtein homeostasisUbiquitin ligases |
| spellingShingle | Wei Jiang Bao-Liang Song Ubiquitin Ligases in Cholesterol Metabolism Diabetes & Metabolism Journal Cholesterol metabolism Protein homeostasis Ubiquitin ligases |
| title | Ubiquitin Ligases in Cholesterol Metabolism |
| title_full | Ubiquitin Ligases in Cholesterol Metabolism |
| title_fullStr | Ubiquitin Ligases in Cholesterol Metabolism |
| title_full_unstemmed | Ubiquitin Ligases in Cholesterol Metabolism |
| title_short | Ubiquitin Ligases in Cholesterol Metabolism |
| title_sort | ubiquitin ligases in cholesterol metabolism |
| topic | Cholesterol metabolism Protein homeostasis Ubiquitin ligases |
| url | http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-38-171.pdf |
| work_keys_str_mv | AT weijiang ubiquitinligasesincholesterolmetabolism AT baoliangsong ubiquitinligasesincholesterolmetabolism |