Is the association between vitamin D, adiponectin, and insulin resistance present in normal weight or obese? A pilot study
Summary: Objective: Obesity is classically associated with vitamin D deficiency. The aim of this study was to investigate the association of vitamin D with serum adiponectin concentration and insulin resistance in normal weight and obese individuals. Research methods and procedures: Cross-sectional...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-02-01
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| Series: | Clinical Nutrition Experimental |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352939318300575 |
| _version_ | 1811323196942581760 |
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| author | Marina Carvalho-Rassbach Jacqueline Isaura Alvarez-Leite Maria de Fátima Haueisen Sander Diniz |
| author_facet | Marina Carvalho-Rassbach Jacqueline Isaura Alvarez-Leite Maria de Fátima Haueisen Sander Diniz |
| author_sort | Marina Carvalho-Rassbach |
| collection | DOAJ |
| description | Summary: Objective: Obesity is classically associated with vitamin D deficiency. The aim of this study was to investigate the association of vitamin D with serum adiponectin concentration and insulin resistance in normal weight and obese individuals. Research methods and procedures: Cross-sectional analysis was performed in 76 participants without diabetes (40 obese and 36 normal weight) from a convenience sample of a health counseling center in Belo Horizonte, MG, Brazil. All participants self-reported their skin color as white. Body weight and height were used to calculate body mass index (BMI). Serum insulin, glycemia, vitamin D (25OHD), and adiponectin were evaluated after 12 h fasting. Body fat percentage by electric bioimpedance and waist circumference were analyzed. Pearson's or Spearman's correlation coefficients were calculated. Age- and gender-adjusted associations by multivariate logistic regression were used. Multiplicative interaction terms between 25OHD/adiponectin and BMI were calculated. Results: Participant's mean age was 35 ± 9.5 years; 75% were female, and 65.8% were vitamin D insufficient (25OHD < 20 ng/mL). The mean of 25OHD was 28.4 ± 8.6 ng/mL, median of adiponectin was 204 ng/L, and the median of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was 2.2. There was no association between 25OHD status, adiponectin, and HOMA-IR in total sample or among obese or normal weight individuals. After adjustments, there was an association between 25OHD insufficiency and body fat percentage (odds ratio = 0.94; confidence interval 95% = 0.88 to 0.99, p = 0.04) in the total sample. BMI did not influence the association between 25OHD and adiponectin. Conclusion: There was a negative association between fat percentage and 25OHD status, but there were no associations between 25OHD, adiponectin, and insulin resistance in this sample. Further studies are needed to understand these associations in other populations. Keywords: Obesity, Vitamin D, Adiponectin, Insulin resistance, Vitamins, Abdominal fat |
| first_indexed | 2024-04-13T13:50:48Z |
| format | Article |
| id | doaj.art-241a119779424e3f93aa43d95cf01199 |
| institution | Directory Open Access Journal |
| issn | 2352-9393 |
| language | English |
| last_indexed | 2024-04-13T13:50:48Z |
| publishDate | 2019-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Experimental |
| spelling | doaj.art-241a119779424e3f93aa43d95cf011992022-12-22T02:44:21ZengElsevierClinical Nutrition Experimental2352-93932019-02-01238088Is the association between vitamin D, adiponectin, and insulin resistance present in normal weight or obese? A pilot studyMarina Carvalho-Rassbach0Jacqueline Isaura Alvarez-Leite1Maria de Fátima Haueisen Sander Diniz2Postgraduate Student of Saúde do Adulto, Universidade Federal de Minas Gerais (UFMG), Brazil; Corresponding author. Postgraduate Program, Faculty of Medicine, R. Rodrigues Caldas 670, 14 Floor, Belo Horizonte, MG 30190-120, Brazil.Department of Biochemistry and Immunology, UFMG, BrazilDepartment of Internal Medicine, UFMG, Endocrinology and Metabolism Unit, Hospital das Clínicas, BrazilSummary: Objective: Obesity is classically associated with vitamin D deficiency. The aim of this study was to investigate the association of vitamin D with serum adiponectin concentration and insulin resistance in normal weight and obese individuals. Research methods and procedures: Cross-sectional analysis was performed in 76 participants without diabetes (40 obese and 36 normal weight) from a convenience sample of a health counseling center in Belo Horizonte, MG, Brazil. All participants self-reported their skin color as white. Body weight and height were used to calculate body mass index (BMI). Serum insulin, glycemia, vitamin D (25OHD), and adiponectin were evaluated after 12 h fasting. Body fat percentage by electric bioimpedance and waist circumference were analyzed. Pearson's or Spearman's correlation coefficients were calculated. Age- and gender-adjusted associations by multivariate logistic regression were used. Multiplicative interaction terms between 25OHD/adiponectin and BMI were calculated. Results: Participant's mean age was 35 ± 9.5 years; 75% were female, and 65.8% were vitamin D insufficient (25OHD < 20 ng/mL). The mean of 25OHD was 28.4 ± 8.6 ng/mL, median of adiponectin was 204 ng/L, and the median of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) was 2.2. There was no association between 25OHD status, adiponectin, and HOMA-IR in total sample or among obese or normal weight individuals. After adjustments, there was an association between 25OHD insufficiency and body fat percentage (odds ratio = 0.94; confidence interval 95% = 0.88 to 0.99, p = 0.04) in the total sample. BMI did not influence the association between 25OHD and adiponectin. Conclusion: There was a negative association between fat percentage and 25OHD status, but there were no associations between 25OHD, adiponectin, and insulin resistance in this sample. Further studies are needed to understand these associations in other populations. Keywords: Obesity, Vitamin D, Adiponectin, Insulin resistance, Vitamins, Abdominal fathttp://www.sciencedirect.com/science/article/pii/S2352939318300575 |
| spellingShingle | Marina Carvalho-Rassbach Jacqueline Isaura Alvarez-Leite Maria de Fátima Haueisen Sander Diniz Is the association between vitamin D, adiponectin, and insulin resistance present in normal weight or obese? A pilot study Clinical Nutrition Experimental |
| title | Is the association between vitamin D, adiponectin, and insulin resistance present in normal weight or obese? A pilot study |
| title_full | Is the association between vitamin D, adiponectin, and insulin resistance present in normal weight or obese? A pilot study |
| title_fullStr | Is the association between vitamin D, adiponectin, and insulin resistance present in normal weight or obese? A pilot study |
| title_full_unstemmed | Is the association between vitamin D, adiponectin, and insulin resistance present in normal weight or obese? A pilot study |
| title_short | Is the association between vitamin D, adiponectin, and insulin resistance present in normal weight or obese? A pilot study |
| title_sort | is the association between vitamin d adiponectin and insulin resistance present in normal weight or obese a pilot study |
| url | http://www.sciencedirect.com/science/article/pii/S2352939318300575 |
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