The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer

The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer

Currently, oligonucleotide therapy has emerged as a new paradigm in the treatment of human diseases. In many cases, however, therapeutic oligonucleotides cannot be used directly without modification. Chemical modification or the conjugation of therapeutic oligonucleotides is required to increase the...

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Bibliographic Details
Main Authors: Irina V. Varizhuk, Vladimir B. Tsvetkov, Ilya Yu. Toropygin, Andrey A. Stomakhin, Natalia A. Kolganova, Sergei A. Surzhikov, Edward N. Timofeev
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
therapeutic oligonucleotide
thrombin aptamer
peptide conjugate
anticoagulant
G-quadruplex
Online Access:https://www.mdpi.com/1999-4923/15/2/604

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https://www.mdpi.com/1999-4923/15/2/604

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