The Role of Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical
Cardiovascular disease (CVD) is directly linked to diabetes mellitus (DM), and its morbidity and mortality are rising at an alarming rate. Individuals with DM experience significantly worse clinical outcomes due to heart failure as a CVD consequence than non-diabetic patients. Hyperglycemia is the m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/11/1344 |
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| author | Syaifuzah Sapian Izatus Shima Taib Haliza Katas Jalifah Latip Satirah Zainalabidin Zariyantey Abd Hamid Nur Najmi Mohamad Anuar Siti Balkis Budin |
| author_facet | Syaifuzah Sapian Izatus Shima Taib Haliza Katas Jalifah Latip Satirah Zainalabidin Zariyantey Abd Hamid Nur Najmi Mohamad Anuar Siti Balkis Budin |
| author_sort | Syaifuzah Sapian |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is directly linked to diabetes mellitus (DM), and its morbidity and mortality are rising at an alarming rate. Individuals with DM experience significantly worse clinical outcomes due to heart failure as a CVD consequence than non-diabetic patients. Hyperglycemia is the main culprit that triggers the activation of oxidative damage, inflammation, fibrosis, and apoptosis pathways that aggravate diabetic CVD progression. In recent years, the development of phytochemical-based nutraceutical products for diabetic treatment has risen due to their therapeutic properties. Anthocyanin, which can be found in various types of plants, has been proposed for preventing and treating various diseases, and has elicited excellent antioxidative, anti-inflammation, anti-fibrosis, and anti-apoptosis effects. In preclinical and clinical studies, plants rich in anthocyanin have been reported to attenuate diabetic CVD. Therefore, the development of anthocyanin as a nutraceutical in managing diabetic CVD is in demand. In this review, we unveil the role of anthocyanin in modulating diabetic CVD, and its potential to be developed as a nutraceutical for a therapeutic strategy in managing CVD associated with DM. |
| first_indexed | 2024-03-09T18:44:45Z |
| format | Article |
| id | doaj.art-241b607ab28548319c0d2f2085516ebc |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T18:44:45Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-241b607ab28548319c0d2f2085516ebc2023-11-24T06:18:26ZengMDPI AGPharmaceuticals1424-82472022-10-011511134410.3390/ph15111344The Role of Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a NutraceuticalSyaifuzah Sapian0Izatus Shima Taib1Haliza Katas2Jalifah Latip3Satirah Zainalabidin4Zariyantey Abd Hamid5Nur Najmi Mohamad Anuar6Siti Balkis Budin7Center for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCenter for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCentre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaDepartment of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 46300, MalaysiaProgramme of Biomedical Science, Centre for Toxicology and Health Risk Research, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCenter for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaProgramme of Biomedical Science, Centre for Toxicology and Health Risk Research, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCenter for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCardiovascular disease (CVD) is directly linked to diabetes mellitus (DM), and its morbidity and mortality are rising at an alarming rate. Individuals with DM experience significantly worse clinical outcomes due to heart failure as a CVD consequence than non-diabetic patients. Hyperglycemia is the main culprit that triggers the activation of oxidative damage, inflammation, fibrosis, and apoptosis pathways that aggravate diabetic CVD progression. In recent years, the development of phytochemical-based nutraceutical products for diabetic treatment has risen due to their therapeutic properties. Anthocyanin, which can be found in various types of plants, has been proposed for preventing and treating various diseases, and has elicited excellent antioxidative, anti-inflammation, anti-fibrosis, and anti-apoptosis effects. In preclinical and clinical studies, plants rich in anthocyanin have been reported to attenuate diabetic CVD. Therefore, the development of anthocyanin as a nutraceutical in managing diabetic CVD is in demand. In this review, we unveil the role of anthocyanin in modulating diabetic CVD, and its potential to be developed as a nutraceutical for a therapeutic strategy in managing CVD associated with DM.https://www.mdpi.com/1424-8247/15/11/1344vascular dysfunctioncardiac dysfunctioncyanidindelphinidinoxidative stressinflammation |
| spellingShingle | Syaifuzah Sapian Izatus Shima Taib Haliza Katas Jalifah Latip Satirah Zainalabidin Zariyantey Abd Hamid Nur Najmi Mohamad Anuar Siti Balkis Budin The Role of Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical Pharmaceuticals vascular dysfunction cardiac dysfunction cyanidin delphinidin oxidative stress inflammation |
| title | The Role of Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical |
| title_full | The Role of Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical |
| title_fullStr | The Role of Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical |
| title_full_unstemmed | The Role of Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical |
| title_short | The Role of Anthocyanin in Modulating Diabetic Cardiovascular Disease and Its Potential to Be Developed as a Nutraceutical |
| title_sort | role of anthocyanin in modulating diabetic cardiovascular disease and its potential to be developed as a nutraceutical |
| topic | vascular dysfunction cardiac dysfunction cyanidin delphinidin oxidative stress inflammation |
| url | https://www.mdpi.com/1424-8247/15/11/1344 |
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