Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways
Anxiety is a prevalent mental illness known for its high incidence, comorbidity, and tendency to recur, posing significant societal and individual burdens. Studies have highlighted Interleukin-19 (IL-19) as having potential relevance in neuropsychiatric disorders. Our previous research revealed that...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923024000856 |
| _version_ | 1831877536040091648 |
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| author | Yuting Jiang Lihong Xu Yifan Cao Fantao Meng Shujun Jiang Mengyu Yang Ziteng Zheng Yi Zhang Lu Yang Meiqin Wang Guizhi Sun Jing Liu Chen Li Minghu Cui |
| author_facet | Yuting Jiang Lihong Xu Yifan Cao Fantao Meng Shujun Jiang Mengyu Yang Ziteng Zheng Yi Zhang Lu Yang Meiqin Wang Guizhi Sun Jing Liu Chen Li Minghu Cui |
| author_sort | Yuting Jiang |
| collection | DOAJ |
| description | Anxiety is a prevalent mental illness known for its high incidence, comorbidity, and tendency to recur, posing significant societal and individual burdens. Studies have highlighted Interleukin-19 (IL-19) as having potential relevance in neuropsychiatric disorders. Our previous research revealed that IL-19 overexpression in colonies exacerbated anxiety-related behaviors induced by dextran sodium sulfate/stress. However, the precise role and molecular mechanisms of IL-19 in anxiety regulation remain uncertain. In this study, we initiated an acute restraint stress (ARS)-induced anxious mouse model and identified heightened expression of IL-19 and IL-20Rα in the medial prefrontal cortex (mPFC) of ARS mice. Notably, IL-19 and IL-20Rα were predominantly present in the excitatory pyramidal neurons of the mPFC under both basal and ARS conditions. Utilizing the adeno-associated virus (AAV) strategy, we demonstrated that IL-19 overexpression in the mPFC induced anxiety-related behaviors and elevated stress susceptibility. Additionally, we observed decreased protein levels of brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95) in the mPFC of IL-19 overexpression mice, accompanied by reduced phosphorylation of in the p38, JNK, and Erk signaling pathways. These findings emphasize the role of IL-19 in modulating anxiety-related behaviors within the mPFC and suggest its potential as a pathological gene and therapeutic target for anxiety. |
| first_indexed | 2024-04-24T07:05:07Z |
| format | Article |
| id | doaj.art-241c134c28ed4321b5463a6facccd3a9 |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2025-03-21T21:17:24Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-241c134c28ed4321b5463a6facccd3a92024-05-29T04:59:52ZengElsevierBrain Research Bulletin1873-27472024-06-01212110952Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathwaysYuting Jiang0Lihong Xu1Yifan Cao2Fantao Meng3Shujun Jiang4Mengyu Yang5Ziteng Zheng6Yi Zhang7Lu Yang8Meiqin Wang9Guizhi Sun10Jing Liu11Chen Li12Minghu Cui13Department of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Physiology, Binzhou Medical University, Shandong, ChinaDepartment of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaMedical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China; Department of Physiology, Binzhou Medical University, Shandong, ChinaDepartment of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, ChinaDepartment of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China; Correspondence to: Medical Research Center Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, Shandong 256603, China.Department of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China; Correspondence to: Medical Research Center Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, Shandong 256603, China.Department of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China; Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China; Correspondence to: Department of Psychology Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, Shandong 256603, China.Anxiety is a prevalent mental illness known for its high incidence, comorbidity, and tendency to recur, posing significant societal and individual burdens. Studies have highlighted Interleukin-19 (IL-19) as having potential relevance in neuropsychiatric disorders. Our previous research revealed that IL-19 overexpression in colonies exacerbated anxiety-related behaviors induced by dextran sodium sulfate/stress. However, the precise role and molecular mechanisms of IL-19 in anxiety regulation remain uncertain. In this study, we initiated an acute restraint stress (ARS)-induced anxious mouse model and identified heightened expression of IL-19 and IL-20Rα in the medial prefrontal cortex (mPFC) of ARS mice. Notably, IL-19 and IL-20Rα were predominantly present in the excitatory pyramidal neurons of the mPFC under both basal and ARS conditions. Utilizing the adeno-associated virus (AAV) strategy, we demonstrated that IL-19 overexpression in the mPFC induced anxiety-related behaviors and elevated stress susceptibility. Additionally, we observed decreased protein levels of brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95) in the mPFC of IL-19 overexpression mice, accompanied by reduced phosphorylation of in the p38, JNK, and Erk signaling pathways. These findings emphasize the role of IL-19 in modulating anxiety-related behaviors within the mPFC and suggest its potential as a pathological gene and therapeutic target for anxiety.http://www.sciencedirect.com/science/article/pii/S0361923024000856Acute restraint stressAnxietyMedial prefrontal cortexInterleukin-19Interleukin 20α receptor |
| spellingShingle | Yuting Jiang Lihong Xu Yifan Cao Fantao Meng Shujun Jiang Mengyu Yang Ziteng Zheng Yi Zhang Lu Yang Meiqin Wang Guizhi Sun Jing Liu Chen Li Minghu Cui Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways Brain Research Bulletin Acute restraint stress Anxiety Medial prefrontal cortex Interleukin-19 Interleukin 20α receptor |
| title | Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways |
| title_full | Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways |
| title_fullStr | Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways |
| title_full_unstemmed | Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways |
| title_short | Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways |
| title_sort | effects of interleukin 19 overexpression in the medial prefrontal cortex on anxiety related behaviors bdnf expression and p38 jnk erk pathways |
| topic | Acute restraint stress Anxiety Medial prefrontal cortex Interleukin-19 Interleukin 20α receptor |
| url | http://www.sciencedirect.com/science/article/pii/S0361923024000856 |
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