Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent Way
Increasing evidence indicates that photobiomodulation, based on tissue irradiation with photons in the red to near-infrared spectrum, may be an effective therapeutic approach to central nervous system disorders. Although nervous system functionality has been shown to be affected by photons in animal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/13/10977 |
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| author | Chiara Cervetto Andrea Amaroli Sarah Amato Elena Gatta Alberto Diaspro Guido Maura Antonio Signore Stefano Benedicenti Manuela Marcoli |
| author_facet | Chiara Cervetto Andrea Amaroli Sarah Amato Elena Gatta Alberto Diaspro Guido Maura Antonio Signore Stefano Benedicenti Manuela Marcoli |
| author_sort | Chiara Cervetto |
| collection | DOAJ |
| description | Increasing evidence indicates that photobiomodulation, based on tissue irradiation with photons in the red to near-infrared spectrum, may be an effective therapeutic approach to central nervous system disorders. Although nervous system functionality has been shown to be affected by photons in animal models, as well as in preliminary evidence in healthy subjects or in patients with neuropsychiatric disorders, the mechanisms involved in the photobiomodulation effects have not yet been clarified. We previously observed that photobiomodulation could stimulate glutamate release. Here, we investigate mechanisms potentially involved in the glutamate-releasing effect of photons from adult mouse cerebrocortical nerve terminals. We report evidence of photon ability to induce an exocytotic vesicular release of glutamate from the terminals of glutamatergic neurons in a power-dependent way. It can be hypothesized that photobiomodulation, depending on the potency, can release glutamate in a potentially neurotoxic or physiological range. |
| first_indexed | 2024-03-11T01:38:50Z |
| format | Article |
| id | doaj.art-241c557e9753474fa6c5669f1325f2b4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:38:50Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-241c557e9753474fa6c5669f1325f2b42023-11-18T16:46:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124131097710.3390/ijms241310977Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent WayChiara Cervetto0Andrea Amaroli1Sarah Amato2Elena Gatta3Alberto Diaspro4Guido Maura5Antonio Signore6Stefano Benedicenti7Manuela Marcoli8Department of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Viale Cembrano 4, 16148 Genova, ItalyDepartment of Earth, Environment and Life Sciences, University of Genova, Viale Benedetto XV 5, 16132 Genova, ItalyDepartment of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Viale Cembrano 4, 16148 Genova, ItalyDIFILAB, Department of Physics, University of Genova, Via Dodecaneso 33, 16146 Genova, ItalyDIFILAB, Department of Physics, University of Genova, Via Dodecaneso 33, 16146 Genova, ItalyDepartment of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Viale Cembrano 4, 16148 Genova, ItalyTherapeutic Dentistry Department, Institute of Dentistry, Sechenov First Moscow State Medical University, Trubetskaya Str. 8, b. 2, 119992 Moskow, RussiaDepartment of Surgical Sciences and Integrated Diagnostics, University of Genova, Viale Benedetto XV 6, 16132 Genova, ItalyDepartment of Pharmacy, Section of Pharmacology and Toxicology, University of Genova, Viale Cembrano 4, 16148 Genova, ItalyIncreasing evidence indicates that photobiomodulation, based on tissue irradiation with photons in the red to near-infrared spectrum, may be an effective therapeutic approach to central nervous system disorders. Although nervous system functionality has been shown to be affected by photons in animal models, as well as in preliminary evidence in healthy subjects or in patients with neuropsychiatric disorders, the mechanisms involved in the photobiomodulation effects have not yet been clarified. We previously observed that photobiomodulation could stimulate glutamate release. Here, we investigate mechanisms potentially involved in the glutamate-releasing effect of photons from adult mouse cerebrocortical nerve terminals. We report evidence of photon ability to induce an exocytotic vesicular release of glutamate from the terminals of glutamatergic neurons in a power-dependent way. It can be hypothesized that photobiomodulation, depending on the potency, can release glutamate in a potentially neurotoxic or physiological range.https://www.mdpi.com/1422-0067/24/13/10977laser therapyphotobiomodulationLLLTlight therapynerve terminalsexocytotic glutamate release |
| spellingShingle | Chiara Cervetto Andrea Amaroli Sarah Amato Elena Gatta Alberto Diaspro Guido Maura Antonio Signore Stefano Benedicenti Manuela Marcoli Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent Way International Journal of Molecular Sciences laser therapy photobiomodulation LLLT light therapy nerve terminals exocytotic glutamate release |
| title | Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent Way |
| title_full | Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent Way |
| title_fullStr | Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent Way |
| title_full_unstemmed | Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent Way |
| title_short | Photons Induce Vesicular Exocytotic Release of Glutamate in a Power-Dependent Way |
| title_sort | photons induce vesicular exocytotic release of glutamate in a power dependent way |
| topic | laser therapy photobiomodulation LLLT light therapy nerve terminals exocytotic glutamate release |
| url | https://www.mdpi.com/1422-0067/24/13/10977 |
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