A Novel Sex-Dependent Target for the Treatment of Postoperative Pain: The NLRP3 Inflammasome

A Novel Sex-Dependent Target for the Treatment of Postoperative Pain: The NLRP3 Inflammasome

In recent years the innate immune system has been shown to be crucial for the pathogenesis of postoperative pain. The mediators released by innate immune cells drive the sensitization of sensory neurons following injury by directly acting on peripheral nerve terminals at the injury site. The predomi...

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Bibliographic Details
Main Authors: Ashley M. Cowie, Bonnie N. Dittel, Cheryl L. Stucky
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neurology
Subjects:
NLRP3
interleukin-1β
sex differences
pain
tissue injury
innate immunity
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00622/full

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