Effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block: a randomized, double-blind, placebo-controlled study
Background Intravenous (IV) dexamethasone prolongs the duration of a peripheral nerve block; however, there is little available information about its optimal effective dose. This study aimed to evaluate the effects of three different doses of IV dexamethasone on the duration of postoperative analges...
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Korean Society of Anesthesiologists
2021-08-01
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| Series: | Korean Journal of Anesthesiology |
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| Online Access: | http://ekja.org/upload/pdf/kja-20640.pdf |
| _version_ | 1818584911339061248 |
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| author | Byung-Gun Kim Woojoo Lee Jang Ho Song Chunwoo Yang Gyung A Heo Hongseok Kim |
| author_facet | Byung-Gun Kim Woojoo Lee Jang Ho Song Chunwoo Yang Gyung A Heo Hongseok Kim |
| author_sort | Byung-Gun Kim |
| collection | DOAJ |
| description | Background Intravenous (IV) dexamethasone prolongs the duration of a peripheral nerve block; however, there is little available information about its optimal effective dose. This study aimed to evaluate the effects of three different doses of IV dexamethasone on the duration of postoperative analgesia to determine the optimal effective dose for a sciatic nerve block. Methods Patients scheduled for foot and ankle surgery were randomly assigned to receive normal saline or IV dexamethasone (2.5 mg, 5 mg, or 10 mg). An ultrasound-guided popliteal sciatic nerve block was performed using 0.75% ropivacaine (20 ml) before general anesthesia. The duration of postoperative analgesia was the primary outcome, and pain scores, use of rescue analgesia, onset time, adverse effects, and patient satisfaction were assessed as secondary outcomes. Results Compared with the control group, the postoperative analgesic duration of the sciatic nerve block was prolonged in groups receiving IV dexamethasone 10 mg (P < 0.001), but not in the groups receiving IV dexamethasone 2.5 mg or 5 mg. The use of rescue analgesics was significantly different among the four groups 24 h postoperatively (P = 0.001) and similar thereafter. However, pain scores were not significantly different among the four groups 24 h postoperatively. There were no statistically significant differences in the other secondary outcomes among the four groups. Conclusions This study demonstrated that compared to the controls, only IV dexamethasone 10 mg increased the duration of postoperative analgesia following a sciatic nerve block for foot and ankle surgery without the occurrence of adverse events. |
| first_indexed | 2024-12-16T08:28:42Z |
| format | Article |
| id | doaj.art-24228bf3600c4eacb0e41c2b39c0233c |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-16T08:28:42Z |
| publishDate | 2021-08-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-24228bf3600c4eacb0e41c2b39c0233c2022-12-21T22:37:56ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632021-08-0174431732410.4097/kja.206408732Effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block: a randomized, double-blind, placebo-controlled studyByung-Gun Kim0Woojoo Lee1Jang Ho Song2Chunwoo Yang3Gyung A Heo4Hongseok Kim5 Department of Anesthesiology and Pain Medicine, Inha University School of Medicine, Incheon, Korea Department of Public Health Science, Graduate School of Public Health, Seoul National University, Seoul, Korea Department of Anesthesiology and Pain Medicine, Inha University School of Medicine, Incheon, Korea Department of Anesthesiology and Pain Medicine, Inha University School of Medicine, Incheon, Korea Department of Anesthesiology and Pain Medicine, Inha University School of Medicine, Incheon, Korea Department of Anesthesiology and Pain Medicine, Inha University School of Medicine, Incheon, KoreaBackground Intravenous (IV) dexamethasone prolongs the duration of a peripheral nerve block; however, there is little available information about its optimal effective dose. This study aimed to evaluate the effects of three different doses of IV dexamethasone on the duration of postoperative analgesia to determine the optimal effective dose for a sciatic nerve block. Methods Patients scheduled for foot and ankle surgery were randomly assigned to receive normal saline or IV dexamethasone (2.5 mg, 5 mg, or 10 mg). An ultrasound-guided popliteal sciatic nerve block was performed using 0.75% ropivacaine (20 ml) before general anesthesia. The duration of postoperative analgesia was the primary outcome, and pain scores, use of rescue analgesia, onset time, adverse effects, and patient satisfaction were assessed as secondary outcomes. Results Compared with the control group, the postoperative analgesic duration of the sciatic nerve block was prolonged in groups receiving IV dexamethasone 10 mg (P < 0.001), but not in the groups receiving IV dexamethasone 2.5 mg or 5 mg. The use of rescue analgesics was significantly different among the four groups 24 h postoperatively (P = 0.001) and similar thereafter. However, pain scores were not significantly different among the four groups 24 h postoperatively. There were no statistically significant differences in the other secondary outcomes among the four groups. Conclusions This study demonstrated that compared to the controls, only IV dexamethasone 10 mg increased the duration of postoperative analgesia following a sciatic nerve block for foot and ankle surgery without the occurrence of adverse events.http://ekja.org/upload/pdf/kja-20640.pdfanalgesiaankledexamethasonefootintravenous injectionsnerve blockpharmaceutic adjuvantssciatic nerve |
| spellingShingle | Byung-Gun Kim Woojoo Lee Jang Ho Song Chunwoo Yang Gyung A Heo Hongseok Kim Effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block: a randomized, double-blind, placebo-controlled study Korean Journal of Anesthesiology analgesia ankle dexamethasone foot intravenous injections nerve block pharmaceutic adjuvants sciatic nerve |
| title | Effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block: a randomized, double-blind, placebo-controlled study |
| title_full | Effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block: a randomized, double-blind, placebo-controlled study |
| title_fullStr | Effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block: a randomized, double-blind, placebo-controlled study |
| title_full_unstemmed | Effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block: a randomized, double-blind, placebo-controlled study |
| title_short | Effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block: a randomized, double-blind, placebo-controlled study |
| title_sort | effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block a randomized double blind placebo controlled study |
| topic | analgesia ankle dexamethasone foot intravenous injections nerve block pharmaceutic adjuvants sciatic nerve |
| url | http://ekja.org/upload/pdf/kja-20640.pdf |
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