The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells

The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells

Abstract Background Evasion from programmed cell death is a hallmark of cancer and can be achieved in cancer cells by overexpression of inhibitor of apoptosis proteins (IAPs). Second mitochondria-derived activator of caspases (SMAC) directly bind to IAPs and promote apoptosis; thus, SMAC mimetics ha...

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Bibliographic Details
Main Authors: Brianna M. Craver, Thanh Kim Nguyen, Jenny Nguyen, Hellen Nguyen, Christy Huynh, Sarah J. Morse, Angela G. Fleischman
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Experimental Hematology & Oncology
Subjects:
Myeloproliferative neoplasm
SMAC mimetic
TNFα
Online Access:https://doi.org/10.1186/s40164-019-0157-6

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