Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion
Chemo-resistance and immune evasion are major challenges in osteosarcoma treatment. Here the authors show that doxorubicin promotes IL-18 secretion by tumor associated macrophages inducing LAT2-dependent CD47 upregulation in osteosarcoma cells, suggesting LAT2 inhibition as a therapeutic option in c...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34064-4 |
| _version_ | 1811249972519108608 |
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| author | Zenan Wang Binghao Li Shan Li Wenlong Lin Zhan Wang Shengdong Wang Weida Chen Wei Shi Tao Chen Hao Zhou Eloy Yinwang Wenkan Zhang Haochen Mou Xupeng Chai Jiahao Zhang Zhimin Lu Zhaoming Ye |
| author_facet | Zenan Wang Binghao Li Shan Li Wenlong Lin Zhan Wang Shengdong Wang Weida Chen Wei Shi Tao Chen Hao Zhou Eloy Yinwang Wenkan Zhang Haochen Mou Xupeng Chai Jiahao Zhang Zhimin Lu Zhaoming Ye |
| author_sort | Zenan Wang |
| collection | DOAJ |
| description | Chemo-resistance and immune evasion are major challenges in osteosarcoma treatment. Here the authors show that doxorubicin promotes IL-18 secretion by tumor associated macrophages inducing LAT2-dependent CD47 upregulation in osteosarcoma cells, suggesting LAT2 inhibition as a therapeutic option in combination with doxorubicin. |
| first_indexed | 2024-04-12T15:56:52Z |
| format | Article |
| id | doaj.art-242307c6508642058c15bbbd18691354 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T15:56:52Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-242307c6508642058c15bbbd186913542022-12-22T03:26:20ZengNature PortfolioNature Communications2041-17232022-10-0113111910.1038/s41467-022-34064-4Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasionZenan Wang0Binghao Li1Shan Li2Wenlong Lin3Zhan Wang4Shengdong Wang5Weida Chen6Wei Shi7Tao Chen8Hao Zhou9Eloy Yinwang10Wenkan Zhang11Haochen Mou12Xupeng Chai13Jiahao Zhang14Zhimin Lu15Zhaoming Ye16Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Hepatobiliary and Pancreatic Surgery and Zhejiang Provincial Key Laboratory of Pancreatic Disease of The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Hepatobiliary and Pancreatic Surgery and Zhejiang Provincial Key Laboratory of Pancreatic Disease of The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of MedicineDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineChemo-resistance and immune evasion are major challenges in osteosarcoma treatment. Here the authors show that doxorubicin promotes IL-18 secretion by tumor associated macrophages inducing LAT2-dependent CD47 upregulation in osteosarcoma cells, suggesting LAT2 inhibition as a therapeutic option in combination with doxorubicin.https://doi.org/10.1038/s41467-022-34064-4 |
| spellingShingle | Zenan Wang Binghao Li Shan Li Wenlong Lin Zhan Wang Shengdong Wang Weida Chen Wei Shi Tao Chen Hao Zhou Eloy Yinwang Wenkan Zhang Haochen Mou Xupeng Chai Jiahao Zhang Zhimin Lu Zhaoming Ye Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion Nature Communications |
| title | Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion |
| title_full | Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion |
| title_fullStr | Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion |
| title_full_unstemmed | Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion |
| title_short | Metabolic control of CD47 expression through LAT2-mediated amino acid uptake promotes tumor immune evasion |
| title_sort | metabolic control of cd47 expression through lat2 mediated amino acid uptake promotes tumor immune evasion |
| url | https://doi.org/10.1038/s41467-022-34064-4 |
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