Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion

Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion

Background: Transjugular intrahepatic portosystemic shunts (TIPS) have become a widely accepted tool in the treatment of patients with symptomatic portal hypertension. The aim of our study was to assess glycogen phosphorylase BB (GPBB) concentration in relation to echocardiographic and haemodynamic...

Full description

Bibliographic Details
Main Authors: Martina Vasatova, Radek Pudil, Tomas Buchler, Iva Karesova, Vaclav Safka, Tomas Fejfar, Petr Hulek
Format: Article
Language:English
Published: Palacký University Olomouc, Faculty of Medicine and Dentistry 2015-09-01
Series:Biomedical Papers
Subjects:
glycogen phosphorylase bb
cardiac marker
cirrhosis
biochip
portal hypertension
tips
Online Access:https://biomed.papers.upol.cz/artkey/bio-201503-0017_Glycogen_phosphorylase_BB_levels_are_associated_with_haemodynamic_parameters_in_cirrhotic_patients_undergoing_t.php
Description
Summary:Background: Transjugular intrahepatic portosystemic shunts (TIPS) have become a widely accepted tool in the treatment of patients with symptomatic portal hypertension. The aim of our study was to assess glycogen phosphorylase BB (GPBB) concentration in relation to echocardiographic and haemodynamic parameters in patients before and after TIPS insertion. Methods: The study population consisted of 55 patients (38 men and 17 women, age 55.6±8.9 years, range 37-74 years) with liver cirrhosis treated with transjugular portosystemic shunting. GPBB, echocardiographic, and haemodynamic parameters were measured before TIPS insertion and 24 h after the procedure. GPBB concentrations were assessed using the Cardiac Array for Evidence Investigator protein biochip. Correlation between parameters was assessed using the Spearman's coefficient. Results: Serum post-procedural GPBB concentrations were increased in comparison with baseline (5.58 vs. 2.67 μg/L, P<0.001). GPBB concentration after TIPS significantly correlated with baseline systemic vascular resistence (r=0.330; P=0.017) and cardiac index (r=0.313; P=0.025). Conclusion: GPBB concentration measurement may be a useful tool for monitoring myocardial ischemia during a TIPS procedure.
ISSN:1213-8118
1804-7521

Similar Items