Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion
Background: Transjugular intrahepatic portosystemic shunts (TIPS) have become a widely accepted tool in the treatment of patients with symptomatic portal hypertension. The aim of our study was to assess glycogen phosphorylase BB (GPBB) concentration in relation to echocardiographic and haemodynamic...
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2015-09-01
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| Series: | Biomedical Papers |
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| Online Access: | https://biomed.papers.upol.cz/artkey/bio-201503-0017_Glycogen_phosphorylase_BB_levels_are_associated_with_haemodynamic_parameters_in_cirrhotic_patients_undergoing_t.php |
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| author | Martina Vasatova Radek Pudil Tomas Buchler Iva Karesova Vaclav Safka Tomas Fejfar Petr Hulek |
| author_facet | Martina Vasatova Radek Pudil Tomas Buchler Iva Karesova Vaclav Safka Tomas Fejfar Petr Hulek |
| author_sort | Martina Vasatova |
| collection | DOAJ |
| description | Background: Transjugular intrahepatic portosystemic shunts (TIPS) have become a widely accepted tool in the treatment of patients with symptomatic portal hypertension. The aim of our study was to assess glycogen phosphorylase BB (GPBB) concentration in relation to echocardiographic and haemodynamic parameters in patients before and after TIPS insertion.
Methods: The study population consisted of 55 patients (38 men and 17 women, age 55.6±8.9 years, range 37-74 years) with liver cirrhosis treated with transjugular portosystemic shunting. GPBB, echocardiographic, and haemodynamic parameters were measured before TIPS insertion and 24 h after the procedure. GPBB concentrations were assessed using the Cardiac Array for Evidence Investigator protein biochip. Correlation between parameters was assessed using the Spearman's coefficient.
Results: Serum post-procedural GPBB concentrations were increased in comparison with baseline (5.58 vs. 2.67 μg/L, P<0.001). GPBB concentration after TIPS significantly correlated with baseline systemic vascular resistence (r=0.330; P=0.017) and cardiac index (r=0.313; P=0.025).
Conclusion: GPBB concentration measurement may be a useful tool for monitoring myocardial ischemia during a TIPS procedure. |
| first_indexed | 2024-04-13T16:53:48Z |
| format | Article |
| id | doaj.art-2425357abf224afa823b3fcadbbac14c |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-04-13T16:53:48Z |
| publishDate | 2015-09-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-2425357abf224afa823b3fcadbbac14c2022-12-22T02:38:52ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212015-09-01159343744110.5507/bp.2014.020bio-201503-0017Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertionMartina Vasatova0Radek Pudil1Tomas Buchler2Iva Karesova3Vaclav Safka4Tomas Fejfar5Petr Hulek6Institute of Clinical Biochemistry and Diagnostics, University Hospital in Hradec Kralove, Czech Republic1st Department of Internal Medicine - Cardioangiology, University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in PragueDepartment of Oncology, 1st Faculty of Medicine, Charles University in Prague and Thomayer University Hospital, PragueInstitute of Clinical Biochemistry and Diagnostics, University Hospital in Hradec Kralove, Czech Republic2nd Department of Internal Medicine-Gastroenterology, University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in Prague2nd Department of Internal Medicine-Gastroenterology, University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in Prague2nd Department of Internal Medicine-Gastroenterology, University Hospital in Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in PragueBackground: Transjugular intrahepatic portosystemic shunts (TIPS) have become a widely accepted tool in the treatment of patients with symptomatic portal hypertension. The aim of our study was to assess glycogen phosphorylase BB (GPBB) concentration in relation to echocardiographic and haemodynamic parameters in patients before and after TIPS insertion. Methods: The study population consisted of 55 patients (38 men and 17 women, age 55.6±8.9 years, range 37-74 years) with liver cirrhosis treated with transjugular portosystemic shunting. GPBB, echocardiographic, and haemodynamic parameters were measured before TIPS insertion and 24 h after the procedure. GPBB concentrations were assessed using the Cardiac Array for Evidence Investigator protein biochip. Correlation between parameters was assessed using the Spearman's coefficient. Results: Serum post-procedural GPBB concentrations were increased in comparison with baseline (5.58 vs. 2.67 μg/L, P<0.001). GPBB concentration after TIPS significantly correlated with baseline systemic vascular resistence (r=0.330; P=0.017) and cardiac index (r=0.313; P=0.025). Conclusion: GPBB concentration measurement may be a useful tool for monitoring myocardial ischemia during a TIPS procedure.https://biomed.papers.upol.cz/artkey/bio-201503-0017_Glycogen_phosphorylase_BB_levels_are_associated_with_haemodynamic_parameters_in_cirrhotic_patients_undergoing_t.phpglycogen phosphorylase bbcardiac markercirrhosisbiochipportal hypertensiontips |
| spellingShingle | Martina Vasatova Radek Pudil Tomas Buchler Iva Karesova Vaclav Safka Tomas Fejfar Petr Hulek Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion Biomedical Papers glycogen phosphorylase bb cardiac marker cirrhosis biochip portal hypertension tips |
| title | Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion |
| title_full | Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion |
| title_fullStr | Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion |
| title_full_unstemmed | Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion |
| title_short | Glycogen phosphorylase BB levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion |
| title_sort | glycogen phosphorylase bb levels are associated with haemodynamic parameters in cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt insertion |
| topic | glycogen phosphorylase bb cardiac marker cirrhosis biochip portal hypertension tips |
| url | https://biomed.papers.upol.cz/artkey/bio-201503-0017_Glycogen_phosphorylase_BB_levels_are_associated_with_haemodynamic_parameters_in_cirrhotic_patients_undergoing_t.php |
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