Trp-Containing Antibacterial Peptides Impair Quorum Sensing and Biofilm Development in Multidrug-Resistant Pseudomonas aeruginosa and Exhibit Synergistic Effects With Antibiotics

Trp-Containing Antibacterial Peptides Impair Quorum Sensing and Biofilm Development in Multidrug-Resistant Pseudomonas aeruginosa and Exhibit Synergistic Effects With Antibiotics

Pseudomonas aeruginosa uses quorum sensing (QS) to control virulence, biofilm formation and antibiotic efflux pump expression. The development of effective small molecules targeting the QS system and biofilm formation represents a novel attractive strategy. In this present study, the effects of a se...

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Bibliographic Details
Main Authors: Dejing Shang, Xue Han, Wanying Du, Zhiru Kou, Fengquan Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Microbiology
Subjects:
multidrug-resistant Pseudomonas aeruginosa
Trp-containing peptide
quorum sensing
virulence factor
biofilm
synergy
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.611009/full

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