Anti-Sarcopenic Obesity Effects of <i>Lonicera caerulea</i> Extract in High-Fat Diet-Fed Mice
Sarcopenic obesity is a combination of sarcopenia and obesity. Although several herbal extracts showed improvement on sarcopenia and obesity, respectively, there are few studies on sarcopenic obesity. <i>Lonicera caerulea</i> (honeysuckle berry, HB) can ameliorate metabolic disorders inc...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/10/1633 |
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| author | You-Suk Lee Eun-Jung Park Sung-Min Kim Jong-Yeon Kim Hae-Jeung Lee |
| author_facet | You-Suk Lee Eun-Jung Park Sung-Min Kim Jong-Yeon Kim Hae-Jeung Lee |
| author_sort | You-Suk Lee |
| collection | DOAJ |
| description | Sarcopenic obesity is a combination of sarcopenia and obesity. Although several herbal extracts showed improvement on sarcopenia and obesity, respectively, there are few studies on sarcopenic obesity. <i>Lonicera caerulea</i> (honeysuckle berry, HB) can ameliorate metabolic disorders including obesity. However, its effects on sarcopenic obesity have not been reported yet. Thus, the aim of this study was to investigate whether HB extract might have any beneficial effects on sarcopenic obesity in high-fat diet-induced mice. Forty-eight mice were classified into six groups and treated for eight weeks: (1) NC, normal diet control; (2) HC, high-fat diet control; (3) PC, high-fat diet with orlistat; (4) HB100, high-fat diet with HB extract at 100 mg/kg; (5) HB200, high-fat diet with HB extract at 200 mg/kg; and (6) HB400, high-fat diet with HB extract at 400 mg/kg. Body weight, fat accumulation, muscle mass, muscle strength, and mRNA expression of muscle atrophy were monitored. Compared with the HC group, HB administration showed anti-obesity properties. It reduced body weight gain and modulated serum biochemical parameters and tissue antioxidant enzymes. HB also increased muscle strength and muscle mass of hind legs. In addition, it decreased mRNA expression levels of Atrogin1 and MuRF1 as markers of muscle atrophy but increased PGC1α and SIRT1 as markers of muscle growth. These results suggest that HB might be effective in preventing sarcopenia associated with obesity. |
| first_indexed | 2024-03-10T06:45:05Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T06:45:05Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-2425efa166a44d3eb3b68a082db14f9d2023-11-22T17:17:04ZengMDPI AGAntioxidants2076-39212021-10-011010163310.3390/antiox10101633Anti-Sarcopenic Obesity Effects of <i>Lonicera caerulea</i> Extract in High-Fat Diet-Fed MiceYou-Suk Lee0Eun-Jung Park1Sung-Min Kim2Jong-Yeon Kim3Hae-Jeung Lee4Department of Food and Nutrition, Gachon University, Seongnam-si 13120, Gyeonggi-do, KoreaDepartment of Food and Nutrition, Gachon University, Seongnam-si 13120, Gyeonggi-do, KoreaDepartment of Food Science and Biotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, KoreaDepartment of Food Science and Biotechnology, Gachon University, Seongnam-si 13120, Gyeonggi-do, KoreaDepartment of Food and Nutrition, Gachon University, Seongnam-si 13120, Gyeonggi-do, KoreaSarcopenic obesity is a combination of sarcopenia and obesity. Although several herbal extracts showed improvement on sarcopenia and obesity, respectively, there are few studies on sarcopenic obesity. <i>Lonicera caerulea</i> (honeysuckle berry, HB) can ameliorate metabolic disorders including obesity. However, its effects on sarcopenic obesity have not been reported yet. Thus, the aim of this study was to investigate whether HB extract might have any beneficial effects on sarcopenic obesity in high-fat diet-induced mice. Forty-eight mice were classified into six groups and treated for eight weeks: (1) NC, normal diet control; (2) HC, high-fat diet control; (3) PC, high-fat diet with orlistat; (4) HB100, high-fat diet with HB extract at 100 mg/kg; (5) HB200, high-fat diet with HB extract at 200 mg/kg; and (6) HB400, high-fat diet with HB extract at 400 mg/kg. Body weight, fat accumulation, muscle mass, muscle strength, and mRNA expression of muscle atrophy were monitored. Compared with the HC group, HB administration showed anti-obesity properties. It reduced body weight gain and modulated serum biochemical parameters and tissue antioxidant enzymes. HB also increased muscle strength and muscle mass of hind legs. In addition, it decreased mRNA expression levels of Atrogin1 and MuRF1 as markers of muscle atrophy but increased PGC1α and SIRT1 as markers of muscle growth. These results suggest that HB might be effective in preventing sarcopenia associated with obesity.https://www.mdpi.com/2076-3921/10/10/1633<i>Lonicera caerulea</i>honeysuckle berrysarcopenic obesityhigh-fat diet |
| spellingShingle | You-Suk Lee Eun-Jung Park Sung-Min Kim Jong-Yeon Kim Hae-Jeung Lee Anti-Sarcopenic Obesity Effects of <i>Lonicera caerulea</i> Extract in High-Fat Diet-Fed Mice Antioxidants <i>Lonicera caerulea</i> honeysuckle berry sarcopenic obesity high-fat diet |
| title | Anti-Sarcopenic Obesity Effects of <i>Lonicera caerulea</i> Extract in High-Fat Diet-Fed Mice |
| title_full | Anti-Sarcopenic Obesity Effects of <i>Lonicera caerulea</i> Extract in High-Fat Diet-Fed Mice |
| title_fullStr | Anti-Sarcopenic Obesity Effects of <i>Lonicera caerulea</i> Extract in High-Fat Diet-Fed Mice |
| title_full_unstemmed | Anti-Sarcopenic Obesity Effects of <i>Lonicera caerulea</i> Extract in High-Fat Diet-Fed Mice |
| title_short | Anti-Sarcopenic Obesity Effects of <i>Lonicera caerulea</i> Extract in High-Fat Diet-Fed Mice |
| title_sort | anti sarcopenic obesity effects of i lonicera caerulea i extract in high fat diet fed mice |
| topic | <i>Lonicera caerulea</i> honeysuckle berry sarcopenic obesity high-fat diet |
| url | https://www.mdpi.com/2076-3921/10/10/1633 |
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