Testing Adaptive Therapy Protocols Using Gemcitabine and Capecitabine in a Preclinical Model of Endocrine-Resistant Breast Cancer

Testing Adaptive Therapy Protocols Using Gemcitabine and Capecitabine in a Preclinical Model of Endocrine-Resistant Breast Cancer

Adaptive therapy, an ecologically inspired approach to cancer treatment, aims to overcome resistance and reduce toxicity by leveraging competitive interactions between drug-sensitive and drug-resistant subclones, prioritizing patient survival and quality of life instead of killing the maximum number...

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Bibliographic Details
Main Authors: Sareh Seyedi, Ruthanne Teo, Luke Foster, Daniel Saha, Lida Mina, Donald Northfelt, Karen S. Anderson, Darryl Shibata, Robert Gatenby, Luis H. Cisneros, Brigid Troan, Alexander R. A. Anderson, Carlo C. Maley
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cancers
Subjects:
adaptive therapy
endocrine-resistant MCF7 breast cancer
high-dose therapy
drug-resistant and drug-sensitive subclones
Online Access:https://www.mdpi.com/2072-6694/16/2/257

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