Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice
The pathology of depression involves various factors including the interaction between genes and the environment. The deficiency of n-3 polyunsaturated fatty acids (n-3 PUFAs) in the brain and depressive symptoms are closely related. Krill oil contains abundant amounts of n-3 PUFAs incorporated in p...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1180483/full |
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| author | Hao Zhang Xiaofang Liu Bo Li Yi Zhang Hua Gao Xianyong Zhao Kailiang Leng Zhenhua Song |
| author_facet | Hao Zhang Xiaofang Liu Bo Li Yi Zhang Hua Gao Xianyong Zhao Kailiang Leng Zhenhua Song |
| author_sort | Hao Zhang |
| collection | DOAJ |
| description | The pathology of depression involves various factors including the interaction between genes and the environment. The deficiency of n-3 polyunsaturated fatty acids (n-3 PUFAs) in the brain and depressive symptoms are closely related. Krill oil contains abundant amounts of n-3 PUFAs incorporated in phosphatidylcholine. However, the effect of krill oil treatment on depression-like behaviors induced by chronic stress and its molecular mechanism in the brain remain poorly understood. Here, we used a chronic unpredictable mild stress (CUMS) model to evaluate the effect of krill oil on depression-like behaviors and explored its molecular mechanism through lipid metabolomics and mRNA profiles in the whole brain. We observed that CUMS-induced depression-like behaviors were ameliorated by krill oil supplementation in mice. The metabolism of glycerophospholipids and sphingolipids was disrupted by CUMS treatment, which were ameliorated after krill oil supplementation. Further analysis found that differently expressed genes after krill oil supplementation were mainly enriched in the membrane structures and neuroactive ligand–receptor interaction pathway, which may be responsible for the amelioration of CUMS-induced depression-like behaviors. Altogether, our results uncovered the relationship between lipid metabolism and CUMS, and provided new strategies for the prevention and treatment of depression. |
| first_indexed | 2024-03-12T21:46:00Z |
| format | Article |
| id | doaj.art-24270aed6e8e41d28baa5944ffe7ebce |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-03-12T21:46:00Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-24270aed6e8e41d28baa5944ffe7ebce2023-07-26T11:18:18ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-07-011110.3389/fcell.2023.11804831180483Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in miceHao Zhang0Xiaofang Liu1Bo Li2Yi Zhang3Hua Gao4Xianyong Zhao5Kailiang Leng6Zhenhua Song7Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, ChinaYellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, ChinaDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, ChinaDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, ChinaDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, ChinaYellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, ChinaYellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, ChinaDepartment of Pharmacology, Qingdao University School of Pharmacy, Qingdao, ChinaThe pathology of depression involves various factors including the interaction between genes and the environment. The deficiency of n-3 polyunsaturated fatty acids (n-3 PUFAs) in the brain and depressive symptoms are closely related. Krill oil contains abundant amounts of n-3 PUFAs incorporated in phosphatidylcholine. However, the effect of krill oil treatment on depression-like behaviors induced by chronic stress and its molecular mechanism in the brain remain poorly understood. Here, we used a chronic unpredictable mild stress (CUMS) model to evaluate the effect of krill oil on depression-like behaviors and explored its molecular mechanism through lipid metabolomics and mRNA profiles in the whole brain. We observed that CUMS-induced depression-like behaviors were ameliorated by krill oil supplementation in mice. The metabolism of glycerophospholipids and sphingolipids was disrupted by CUMS treatment, which were ameliorated after krill oil supplementation. Further analysis found that differently expressed genes after krill oil supplementation were mainly enriched in the membrane structures and neuroactive ligand–receptor interaction pathway, which may be responsible for the amelioration of CUMS-induced depression-like behaviors. Altogether, our results uncovered the relationship between lipid metabolism and CUMS, and provided new strategies for the prevention and treatment of depression.https://www.frontiersin.org/articles/10.3389/fcell.2023.1180483/fullmajor depressive disorderCUMSkrill oiltranscriptome sequencinglipid metabolism |
| spellingShingle | Hao Zhang Xiaofang Liu Bo Li Yi Zhang Hua Gao Xianyong Zhao Kailiang Leng Zhenhua Song Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice Frontiers in Cell and Developmental Biology major depressive disorder CUMS krill oil transcriptome sequencing lipid metabolism |
| title | Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice |
| title_full | Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice |
| title_fullStr | Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice |
| title_full_unstemmed | Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice |
| title_short | Krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress-induced depression-like behavior in mice |
| title_sort | krill oil treatment ameliorates lipid metabolism imbalance in chronic unpredicted mild stress induced depression like behavior in mice |
| topic | major depressive disorder CUMS krill oil transcriptome sequencing lipid metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1180483/full |
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