Prescribing frequency and adherence to statins in outpatients with type 2 diabetes mellitus and comorbid cardiovascular diseases
BACKGROUND: Due to the high rate of growth in the incidence and burden of cardiovascular complications, type 2 diabetes mellitus (T2DM) is a significant medical problem in the world. Even in the absence of cardiovascular disease (CVD), patients with T2DM are classified as high and very high risk. In...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2021-01-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/12563 |
| _version_ | 1826588033394147328 |
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| author | Victoriya N. Serebryakova Elena A. Golovina Artem V. Kaveshnikov Vladimir S. Kaveshnikov |
| author_facet | Victoriya N. Serebryakova Elena A. Golovina Artem V. Kaveshnikov Vladimir S. Kaveshnikov |
| author_sort | Victoriya N. Serebryakova |
| collection | DOAJ |
| description | BACKGROUND: Due to the high rate of growth in the incidence and burden of cardiovascular complications, type 2 diabetes mellitus (T2DM) is a significant medical problem in the world. Even in the absence of cardiovascular disease (CVD), patients with T2DM are classified as high and very high risk. In addition to glycemic control, an extremely important aspect of managing this group of patients is prevention of cardiovascular complications. T2DM and hyperlipidemia determines the target group for statins. At the same time, little is known about the frequency of administration of this class of drugs among people with T2DM.AIM: To study prescribing frequency and adherence to statins in outpatients with T2DM and comorbid cardiovascular diseases.METHODS: 156 patients with type 2 diabetes (87.2% — women, average age — 65.2 years) were examined as part of an outpatient appointment with an endocrinologist at the city polyclinic ofTomsk. We used a standard questionnaire compiled on the basis of adapted international methods, including information on cardiac pathology, medications, income level, and Morisky-Green test. Anthropometric parameters, fasting plasma glucose, glycated hemoglobin, lipid spectrum parameters were measured. Methods of parametric and nonparametric statistics were used for comparisons.RESULTS: Statins were prescribed to 45.0% of the surveyed, and 47.0% of them were constantly taking statins. In 41 and 39% of cases, statins were prescribed by an endocrinologist and a cardiologist, respectively. Those taking statins were characterized by a more severe functional class of angina pectoris (p=0.03), a higher prior myocardial infarction rate (p=0.01). For other concomitant diseases, and also indicators of carbohydrate metabolism, differences between the groups were not revealed. One third of patients were adherent (3–4 points), 2/3 were not adherent to treatment (0–2 points), respectively. Patients with incomes between 1 and 2 cost of living took statins more often than the rest (p=0.021).CONCLUSION: An insufficient frequency of prescription and adherence to statin therapy in patients with T2DM was revealed. In most cases, statins were prescribed by an endocrinologist or cardiologist. Functional class of angina pectoris, prior myocardial infarction and moderate income were associated with more frequent use of statins. To increase the coverage of patients with T2DM with statin treatment, more attention needs to be paid to the issues of CVD prevention from both medical professionals and patients. |
| first_indexed | 2024-03-08T15:19:55Z |
| format | Article |
| id | doaj.art-2428d33350874b619963e3ac1117b050 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2025-03-14T16:34:54Z |
| publishDate | 2021-01-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-2428d33350874b619963e3ac1117b0502025-02-21T09:29:37ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782021-01-0123543444110.14341/DM1256310830Prescribing frequency and adherence to statins in outpatients with type 2 diabetes mellitus and comorbid cardiovascular diseasesVictoriya N. Serebryakova0Elena A. Golovina1Artem V. Kaveshnikov2Vladimir S. Kaveshnikov3Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesBACKGROUND: Due to the high rate of growth in the incidence and burden of cardiovascular complications, type 2 diabetes mellitus (T2DM) is a significant medical problem in the world. Even in the absence of cardiovascular disease (CVD), patients with T2DM are classified as high and very high risk. In addition to glycemic control, an extremely important aspect of managing this group of patients is prevention of cardiovascular complications. T2DM and hyperlipidemia determines the target group for statins. At the same time, little is known about the frequency of administration of this class of drugs among people with T2DM.AIM: To study prescribing frequency and adherence to statins in outpatients with T2DM and comorbid cardiovascular diseases.METHODS: 156 patients with type 2 diabetes (87.2% — women, average age — 65.2 years) were examined as part of an outpatient appointment with an endocrinologist at the city polyclinic ofTomsk. We used a standard questionnaire compiled on the basis of adapted international methods, including information on cardiac pathology, medications, income level, and Morisky-Green test. Anthropometric parameters, fasting plasma glucose, glycated hemoglobin, lipid spectrum parameters were measured. Methods of parametric and nonparametric statistics were used for comparisons.RESULTS: Statins were prescribed to 45.0% of the surveyed, and 47.0% of them were constantly taking statins. In 41 and 39% of cases, statins were prescribed by an endocrinologist and a cardiologist, respectively. Those taking statins were characterized by a more severe functional class of angina pectoris (p=0.03), a higher prior myocardial infarction rate (p=0.01). For other concomitant diseases, and also indicators of carbohydrate metabolism, differences between the groups were not revealed. One third of patients were adherent (3–4 points), 2/3 were not adherent to treatment (0–2 points), respectively. Patients with incomes between 1 and 2 cost of living took statins more often than the rest (p=0.021).CONCLUSION: An insufficient frequency of prescription and adherence to statin therapy in patients with T2DM was revealed. In most cases, statins were prescribed by an endocrinologist or cardiologist. Functional class of angina pectoris, prior myocardial infarction and moderate income were associated with more frequent use of statins. To increase the coverage of patients with T2DM with statin treatment, more attention needs to be paid to the issues of CVD prevention from both medical professionals and patients.https://www.dia-endojournals.ru/jour/article/view/12563diabetes mellituscardiovascular diseasestatinsprescription frequencyadherence to treatmentcomorbidity |
| spellingShingle | Victoriya N. Serebryakova Elena A. Golovina Artem V. Kaveshnikov Vladimir S. Kaveshnikov Prescribing frequency and adherence to statins in outpatients with type 2 diabetes mellitus and comorbid cardiovascular diseases Сахарный диабет diabetes mellitus cardiovascular disease statins prescription frequency adherence to treatment comorbidity |
| title | Prescribing frequency and adherence to statins in outpatients with type 2 diabetes mellitus and comorbid cardiovascular diseases |
| title_full | Prescribing frequency and adherence to statins in outpatients with type 2 diabetes mellitus and comorbid cardiovascular diseases |
| title_fullStr | Prescribing frequency and adherence to statins in outpatients with type 2 diabetes mellitus and comorbid cardiovascular diseases |
| title_full_unstemmed | Prescribing frequency and adherence to statins in outpatients with type 2 diabetes mellitus and comorbid cardiovascular diseases |
| title_short | Prescribing frequency and adherence to statins in outpatients with type 2 diabetes mellitus and comorbid cardiovascular diseases |
| title_sort | prescribing frequency and adherence to statins in outpatients with type 2 diabetes mellitus and comorbid cardiovascular diseases |
| topic | diabetes mellitus cardiovascular disease statins prescription frequency adherence to treatment comorbidity |
| url | https://www.dia-endojournals.ru/jour/article/view/12563 |
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