The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors

The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors

Growth factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and epidermal growth factor (EGF) are important angiogenesis-mediating factors. They exert their effects not only through their respective receptor tyrosine kinases (RTKs), but they also require molecula...

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Bibliographic Details
Main Authors: Alexandra De Zutter, Helena Crijns, Nele Berghmans, Melissa García-Caballero, Lotte Vanbrabant, Noëmie Pörtner, Vincent Vanheule, Paulien Verscheure, Mohammad Mairaj Siddiquei, Ahmed M. Abu El-Asrar, Peter Carmeliet, Pieter Van Wielendaele, Ingrid De Meester, Jo Van Damme, Paul Proost, Sofie Struyf
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
chemokine-derived peptide
heparan sulfate
growth factors
anti-angiogenic activity
Online Access:https://www.mdpi.com/2072-6694/13/20/5090

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